参芪寿胎丸方对黄体功能不全性不孕患者子宫内膜容受性的影响  

Effect of Shenqishoutaiwan on endometrial receptivity of infertility patients with luteal phase deficiency

作　　者：连方[1] 张翔昱[2] 孙振高[1] 张建伟[1] 田姗[2] 

机构地区：[1]山东中医药大学附属医院中西医结合生殖与遗传中心,济南250011 [2]山东中医药大学基础医学院,济南250011

出　　处：《天津中医药》2010年第5期361-364,共4页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然基金委青年基金项目(30901920);山东省科技厅自然基金项目(2R58)

摘　　要：[目的]探讨中药参芪寿胎丸方治疗黄体功能不全性不孕症的疗效及其作用机制。[方法]将60例黄体功能不全性不孕症患者随机分为参芪寿胎丸方合西药组(试验组30例)和西药组(对照组30例),观察治疗前后中医证候改善情况,排卵期血小板活化因子(PAF),黄体中期血清雌二醇(E2)、孕酮(P)水平,黄体期子宫内膜血流、子宫动脉血流,及两组患者的妊娠率。[结果]试验组患者临床肾虚症状改善优于对照组(P<0.05);试验组服药后排卵期PAF及黄体中期血清P水平明显高于对照组(P<0.05);试验组服药后黄体中期子宫动脉血流及子宫内膜血流的阻力指数(RI)(P<0.01)、搏动指数(PI)(P<0.05)均低于对照组;两组患者服药后黄体中期血E2水平均较服药前升高,试验组妊娠率高于对照组,但无显著性差异(P>0.05)。[结论]参芪寿胎丸方治疗黄体功能不全性不孕症有较好的疗效,其机制可能与调节子宫内膜血供,提高黄体功能,改善子宫内膜容受性有关。[Objective] To study the effect of Chinese herbs Shenqishoutaiwan（SQSHTW） prescription in treating sterility women with luteal phase defect and explore its acting mechanism.[Methods] Sixty patients of sterility women with luteal phase defect were randomly divided into the treatment group treated with SQSHTW prescription combined with Western medicine and the control group treated with Western medicine only.The improvement of symptoms of TCM,serum estradiol（E2） and progestone（P） level,blood flow parameters of the endometrial and the blood flow parameters of Uterine artery（PI,RI） on the day of luteal metaphase and serum platelet activating factor（PAF） in Ovulation before and after treatment were observed.[Results] The treatment group was obviously better than the control groupin the improvement of the insufficiency of kidney（P〈0.05）.After treatment serum PAF in Ovulation and the serum progestone level on theday of luteal metaphase in the treatment group was obviously higher than that in the control group（P〈0.05）;blood flow parameters RI ofthe endometrial and the blood flow parameters of Uterine artery on the same day in treatment group and control group were significantlydifferent（P〈0.01）,while PI of the two groups was statistically significant different（P〈0.05）;the serum estradiol level on the day of lutealmetaphase in the two groups was higher than that before treatment,as to the pregnancy rate,the treatment group was higher than controlgroup,but there wasn’t significant difference between them（P〈0.05）.[Conclusions] There was a good effect in treating sterility withluteal phase defect by SQSHTW prescription.It may be related with its action of improving local blood flow and increasing endometrial re-ceptivity.

关 键 词：补肾法 黄体功能不全 子宫内膜容受性 血小板活化因子 

分 类 号：R711.74[医药卫生—妇产科学]