真武汤对肾病综合征大鼠肾脏水通道蛋白2的影响  

Effects of Zhenwu Decoction on renal aquaporins protein 2 in rats with nephropathic syndrome induced by adriamycin

作　　者：孙香娟[1] 常克[1] 张娟[2] 洪颖[3] 

机构地区：[1]成都中医药大学附属医院儿科,成都610073 [2]郑州人民医院,郑州450000 [3]成都中医药大学,成都610075

出　　处：《天津中医药》2010年第5期416-417,共2页Tianjin Journal of Traditional Chinese Medicine

基　　金：成都中医药大学资助项目(ZRYB200719)

摘　　要：[目的]探讨真武汤对阿霉素肾病大鼠水钠潴留的影响及其可能的作用机制。[方法]40只大鼠随机分成正常对照组(NC组),阿霉素肾病组(NS组),阿霉素肾病+真武汤干预组(A组)和阿霉素肾病+福辛普利干预组(F组),每组10只,分别在第1、2、3、4周末时检测各组大鼠24 h尿蛋白,同时在第4周末检测了大鼠血浆精氨酸血管加压素(AVP)含量和肾脏水通道蛋白2(AQP2)蛋白表达。[结果]1)阿霉素大鼠在1周末尿蛋白明显升高,真武汤能明显减少大鼠尿蛋白。2)真武汤能下调阿霉素肾病大鼠肾脏AQP2蛋白的表达。3)真武汤能下调阿霉素肾病大鼠血浆AVP含量。[结论]真武汤能改善阿霉素肾病大鼠水钠潴留状态,其机制可能与其调节肾脏AQP2和血浆AVP含量有关。[Objective] To observe the effects of Zhenwu decoction on water sodium retention of rats with nephropathic syndrome induced by adriamycin and explore its mechanism.[Methods] Nephropathec syndrome was induced by intravenous injection of ADR in 40 rats.They were divided into 4 groups：untreated adrimnycin nephropathy group（NS group）.Adrimnycin nephropathy group treated by Zhen Wu Decoction（A group）,Adriamycin nephropathy group treated by fcxsinopril（F group） and normal control group（NC group）.Urine Albumin were measured at the end of every week.The expression of AQP2 protein in the kidney and AVP were measured at the end of the last week.[Results] Compared with the NS group,urine albumin of A group was significantly reduced.The expression of AQP2 protein in the kidney was decreased in A group.Compared with NS group,AVP of A group was significantly reduced.[Conclusion] Zhenwu Decoction may improve the water sodium retention of Adriamycin nephropathy by changing the content of AQP2 and AVP in rats.

关 键 词：真武汤 阿霉素肾病 水通道蛋白2 血浆精氨酸血管加压素 

分 类 号：R285.5[医药卫生—中药学]