丹酚酸B对猪冠状动脉收缩的影响  

Effect of salvianolic acid B on contraction of porcine coronary artery

作　　者：朱金墙[1] 贾晓旭[1] 康立源[1] 

机构地区：[1]天津中医药大学中医药研究院天津市中药药理重点实验室方剂学教育部重点实验室,天津300193

出　　处：《天津中医药》2010年第5期418-420,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家973项目(2005CB523404);国家自然科学基金项目(30901922)

摘　　要：[目的]观察丹酚酸B(SalB)对猪冠状动脉收缩的影响,并初步探讨其作用机制。[方法]采用离体平滑肌实验方法,观察丹酚酸B对氯化钾(KCl)、氯化钙(CaCl2)和组胺(Hist)诱导离体猪冠状动脉环收缩的影响,以及在无鲈离子(Ca2+)克氏液中,对组胺引起猪冠状动脉环第一相收缩和Ca2+引起第二相收缩的影响。[结果]丹酚酸B可使KCl、CaCl2和Hist诱导猪冠脉环收缩的量-效曲线非平行右移,最大效应降低,呈非竞争性拮抗作用;对冠脉环第一相和第二相收缩均有明显的抑制作用。[结论]丹酚酸B具有扩张冠状动脉的作用,其机制可能与抑制血管平滑肌细胞外钙内流和内钙释放有关。[Objective] To observe the effect of salvianolic acid B（Sal B） on the contraction of porcine coronary artery strips,and investi-gate its mechanism of action.[Methods] Using experimental method of smooth muscle in vitro the effect of Sal B on the contraction of porcine coronary artery strips induced by KCL,CaCl2 and Hist was observed.[Results] Salvianolic acid B had nonparallel right migration effect on KCl,CaCl2 and Histamine induced dose-response curves,and decrease the maximal effect.Moreover,it can greatly inhibit in-tracellular Ca2＋-dependent contraction induced by Histamine,and show relatively little effect on the extracellular Ca2＋-dependent contrac-tion induced by CaCl2.[Conclusion] Salvianolic acid B had a significant relaxing effect on contraction of porcine coronary artery,and had an antagonistic effect on the two kinds of contractions.

关 键 词：丹酚酸B 冠状动脉 收缩 

分 类 号：R285.6[医药卫生—中药学]