模拟微重力对血管内皮细胞影响的研究进展  

Advances in the studies on the effects of simulated microgravity on vascular endothelial cells

作　　者：刘长庭[1] 

机构地区：[1]北京解放军总医院南楼呼吸科,100853

出　　处：《解放军医学杂志》2010年第11期1290-1293,共4页Medical Journal of Chinese People's Liberation Army

基　　金：军队医药卫生“十一五”计划专项滚动课题(06Z048);武器装备预研基金(9140A1704009JB1002);民用航天科研预先研究项目(科工技[2007]302);国家高技术研究发展计划(2008AA12A220)

摘　　要：血管内皮细胞对重力变化极为敏感,微重力可导致血管内皮细胞的结构和功能发生明显改变。随着空间生物医学的不断发展,人们对微重力时血管内皮细胞变化的研究也日趋深入。最新研究发现,模拟微重力可诱导血管内皮的形态、超微结构和细胞骨架等发生改变,对内皮细胞的生长、凋亡和内皮型一氧化氮合酶(eNOS)/一氧化氮(NO)信号通路产生显著影响。这些结构和功能的改变在体外和体内血管内皮细胞中均可发生。目前,虽然对微重力在血管内皮细胞上的效应有了初步了解,但有关其内在机制的研究还比较薄弱,是今后研究的重点。Vascular endothelial cell is one of the cells that are extremely sensitive to the changes of gravity, and microgravity can significantly lead to changes in vascular endothelial cells in structure and function. With the continuous development of space biological medicine, the studies on changes in vascular endothelial cells under microgravity are advancing. It is found recently that simulated microgravity may induce changes in vascular endothelial cells in morphology, uttrastructure and cytoskeleton, remarkably affect the growth, apoptosis and eNOS/NO signal pathway. Moreover, these structural and functional changes are found in vascular endothelial cells both in vivo and in vitro. Despite current preliminary understanding in the effects of microgravity on vascular endothelial cells, the underlying mechanisms which remain incompletely understood will be an erea of active investigation in future.

关 键 词：失重模拟 内皮细胞 毛细血管 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]