高功率毫米波持续急性照射对小鼠行为变化和致死效应影响的初步研究  

Preliminary studies on the effects of high-power millimeter wave on the behavioral changes and lethality in mice

作　　者：徐志伟[1] 吴永红[1] 袁广江[2] 高艳[1] 任长虹[1] 李稚锋[1] 徐寿喜[2] 粟亦农[2] 刘濮鲲[2] 张成岗[1] 

机构地区：[1]北京北京放射医学研究所,100850 [2]北京中国科学院电子学研究所,100190

出　　处：《解放军医学杂志》2010年第11期1298-1301,共4页Medical Journal of Chinese People's Liberation Army

基　　金：国家“重大新药创制”科技专项;国家高技术发展计划项目;军事医学科学院科技创新基金;毫米波国家重点实验室开放课题(K200807,K200924)

摘　　要：目的研究高功率毫米波持续急性照射对小鼠行为和致死的影响。方法使用频率为34.1GHz、最大输出平均功率为20W的高功率毫米波源,分别连通4种角锥喇叭天线垂直辐照动物全身。采用视频监控系统实时跟踪记录动物受毫米波辐照后的行为学变化;采用红外辐照仪实时记录动物背部体表温度变化,并进行量效关系分析。结果 4种角锥喇叭天线持续辐照可导致小鼠行为出现一系列类似变化特征,但不同毫米波参数下出现剧烈反应阈值的时间不同,同时小鼠体表温度也出现明显上升。随着辐照时间延长,小鼠最终趋于死亡,同时体表温度上升达到最大值(体温增幅高达18.43℃)。结论高功率毫米波辐照所导致的热效应是主要的致伤和致死因素,受照射小鼠剧烈反应和死亡时间与输出平均功率大小和辐照距离长短密切相关。Objective To explore the effects of acute and continuous high-power millimeter wave radiation on behaviors and lethality in mice. Methods A 34. 1GHz millimeter wave source with maximum output mean power of 20W connected with four different calibers of pyramidal horn antennas was used to irradiate mice vertically. A real-time video recording system was used to track the behavioral changes of mice exposed to irradiation. An infrared irradiation thermometer was used to record the abdominal surface temperature of mice, followed by dose-effect analysis. Results All mice showed similar behavior changes when exposed to millimeter wave irradiation with different parameters, but the time required for the first-phase of acute response was different. The surface temperature of mice also increased significantly. With the elongation of the irradiation time, mice died eventually, while the temperature increment reached a peak value （18. 43℃）. Conclusion Thermal effect of millimeter wave is the major factor causing injury and death of mice, and the time required for the acute intense response and the time of death are depended on the power of millimeter wave and the distance away from millimeter wave.

关 键 词：高功率毫米波 行为 死亡 皮肤温度 

分 类 号：Q291[生物学—细胞生物学]