NH_4Y_3F_(10)多孔纳米晶的制备及其在MALDI-TOF-MS中的应用(英文)  

Synthesis of Mesoporous NH_4Y_3F_(10) Nanocrystals and Its Application in MALDI-TOF-MS

作　　者：陈志明[1] 耿志荣[1] 张志杨[1] 梅毓华[1] 王志林[1] 

机构地区：[1]南京大学化学化工学院配位化学国家重点实验室,南京210093

出　　处：《无机化学学报》2010年第11期1961-1966,共6页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.20535020,20671051,20721002,90813020);国家重大研究计划项目(2007CB925102);教育部重点研究项目(105081)资助

摘　　要：利用水热法合成出NH4Y3F10多孔纳米晶。由于Y3+离子的激发态能量可以转移给具有较高振动能的有机分子,因此这些多孔纳米晶可以作为基质辅助激光解析电离飞行时间质谱的基体材料,用于检测小分子和聚乙二醇。通过与商品化的基体材料(CHCA、DHB)对比,证明NH4Y3F10多孔纳米晶是一种性能优异的基体材料。这种新型基体材料已经成功应用于有机分子、小肽、C60、缺氧诱导因子(HIFs)和聚乙二醇的分子量的检测,显示出这种基体材料具有广泛的应用前景。Mesoporous NH4Y3F10 nanocrystals were fabricated to serve as a background-free matrix for analysis of small molecules and polyethylene glycols （PEGs） by matrix assisted laser desorption/ionization time of flight mass spectrometry （MALDI-TOF-MS）. The excited state of yttrium ions can transfer energy to high-energy vibrations of organic molecules, which provides the potential technological application in MALDI-TOF-MS analysis of small molecules and PEGs. The advantage of this matrix in comparison with α-cyano-4-hydroxycinnamic acid （CHCA） and 2,5-dihydroxybenzoic acid （DHB） was demonstrated by MALDI-TOF-MS analysis of a peptide mixture. The efficiency of the mesoporous NH4Y3F10 nanocrystals as a novel matrix of low molecular weight compounds was verified by analysis of small peptide, organic compounds, C60 and hypoxia-inducible factors （HIFs）. This matrix is also successfully used for analysis of PEGs （PEG 8000 and PEG 15000）, suggesting a potential for monitoring reactions and for synthetic polymers quality control.

关 键 词：NH4Y3F10 基体 基质辅助激光解析电离飞行时间质谱 小分子 聚乙二醇 

分 类 号：O614.32[理学—无机化学]