梓醇对脑缺血大鼠恢复早期能量代谢的影响  

Effect of catalpol on brain energy metabolism in rats with permanent cerebral ischemia injury

作　　者：刘明[1] 刘洋[1] 孙建宁[1] 玄振玉[2] 

机构地区：[1]北京中医药大学中药药理系,北京100102 [2]苏州玉森新药开发有限公司,苏州215125

出　　处：《中药药理与临床》2010年第5期45-47,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:探讨梓醇对脑缺血大鼠恢复早期脑能量代谢的影响。方法:线栓法建立SD大鼠右侧大脑中动脉永久性缺血模型(pMCAO),于术后3d开始给药,术后14d取材,测定各组大鼠脑组织中钠、钾-三磷酸腺苷酶(Na+、K+-ATPase)和钙、镁-三磷酸腺苷酶(Ca2+、Mg2+-ATase)活性。结果:模型组与假手术组比较,Na+、K+-ATPase和Ca2+、Mg2+-ATPase活性明显降低,表明模型组在术后14d未自行恢复到正常水平。模型组与各给药组比较,Na+、K+-ATPase和Ca2+、Mg2+-ATPase活性差异均具有显著意义。结论:梓醇抑制脑缺血大鼠细胞凋亡的机理与Na+、K+-ATPase和Ca2+、Mg2+-ATPase升高有关。Objective：To investigate the effect of catalpol on brain energy metabolism after permanent cerebral ischemia in rats.Method：Permanent cerebral ischemia was induced by permanent middle cerebral artery occlusion（pMCAO） in rats,and ischemic medication animals received intragastric administration once a day 3-14 days post-ischemia.Animals were killed at 14 days post ischemia.The inorganic phosphate assay method were used to evaluate the activity of Na＋,K＋-ATPase and Ca2＋,Mg2＋-ATPase of ischemic cortex.Result：There were significant difference of two indexes between sham operation group and model group（P〈0.01）.And there were significant difference of two indexs between sham operation group and every treatment group（P〈0.05,P〈0.01）.Conclusion：The mechanism of inhibiting apoptosis of rats brain cell from permanent cerebral ischemia by catalpol is well related to the increase of Na＋,K＋-ATPase and Ca2＋,Mg2＋-ATPase.

关 键 词：梓醇 脑缺血 能量代谢 

分 类 号：R285.5[医药卫生—中药学]