庚型肝炎病毒感染患者自身抗体分析  

Autoimmune antibodies in patients with hepatitis G virus infection *

作　　者：熊华[1] 齐名[1] 王艾丽[1] 虞伟[1] 江舟[1] 武建国[1] 

机构地区：[1]南京军区南京总医院全军医学检验中心

出　　处：《世界华人消化杂志》1999年第4期303-305,共3页World Chinese Journal of Digestology

基　　金：国家人事部科技基金

摘　　要：目的探讨庚型肝炎病毒（ＨＧＶ）感染与机体自身免疫的关系．方法抗ＨＧＶＩｇＧ抗体阳性（ＥＬＩＳＡ法）的各类肝病及其他疾病患者９３例．部分慢性肝炎患者用ＲＴＰＣＲ检测证实为ＨＧＶＲＮＡ阳性．用ＥＬＩＳＡ检测血清中类风湿因子（ＲＦ）、抗双链ＤＮＡ（ｄｓＤＮＡＡｂ）抗体、抗甲状腺球蛋白抗体（ＴＧＡｂ）、抗甲状腺微粒体抗体（ＴＭＡｂ）４种自身抗体．同时用ＥＬＩＳＡ检测乙型肝炎病毒（ＨＢＶ）５项血清标志物（ＨＢｓＡｇ，抗ＨＢｓ，ＨＢｅＡｇ，抗ＨＢｅ，抗ＨＢｃＩｇＧ）和丙型肝炎病毒标志物（抗ＨＣＶＩｇＧ和抗ＨＣＶＩｇＭ）．结果研究对象９３例中有２５例检测出１种以上自身抗体的阳性率为２６９％．其中自身抗体阳性率在单独抗ＨＧＶ阳性者中为１３６％（３／２２）；抗ＨＧＶ阳性合并ＨＢＶ标志物阳性者为１７９％（５／２８）；抗ＨＧＶ阳性合并抗ＨＣＶ阳性者为４００％（１０／２５）；ＨＧＶ，ＨＢＶ，ＨＣＶ标志物全阳性者为３８９％（７／１８）．对照组：自身抗体阳性率为２６１％（３１／１１９）．其中ＨＧＶ，ＨＢＶ，ＨＣＶ标志物全阴性者为１６０％（４／２５）；ＨＢＶ标志物阳性者为２５０％（７／２８）；ＨＣＶ标志物阳性者为２７?AIM To explore the correlation between infection of HGV and autoimmunity. METHODS Ninety three patients with hepatitis G and other diseases with positive anti HGV IgG antibodies were investigated. Autoimmune markers, i.e., rheumatoid factors (RF), anti double strain DNA antibody (ds DNA Ab), anti thyroglobulin antibody (TG Ab) and anti thyromicrosome antibody (TM Ab) in the patient sera were determined by ELISA. The serum markers of hepatitis B virus (HBsAg, anti HBs, HBeAg, anti HBe and anti HBc IgG) and hepatitis C virus (anti HCV IgG and IgM) were detected by ELISA simultaneously. RESULTS One type or more than 1 types of autoimmune antibodies were determined as positive in 26 9% (25/ 93) of patients, while in 26 1% (31/ 119) of controls. No significant difference was found ( P >0 05) between the two groups as well as the matched subgroups, i.e., ①positive anti HGV IgG alone and all negative hepatitis virus markers; ②positive anti HGV IgG plus HBV markers and positive HBV markers alone; ③positive anti HGV IgG plus HCV markers and positive HCV markers alone; and ④positive anti HGV IgG plus HBV markers plus HCV markers and positive HBV markers plus HCV markers alone. CONCLUSION No correlation is found between the HGV serum marker (anti HGV IgG) and 4 types of autoimmune markers.

关 键 词：庚型肝炎病毒 自身抗体 肝炎病毒性 

分 类 号：R512.630.3[医药卫生—内科学]