急性冠状动脉综合征患者外周血Th1/Th2细胞因子水平的变化  

Changes in Th1/Th2 related cytokines in peripheral blood of patients with acute coronary syndrome

作　　者：李晓燕[1] 阴其云[1] 黄志刚[1] 刘科卫[1] 韩淑芳[1] 

机构地区：[1]济南军区总医院心血管内科,济南市250031

出　　处：《中华老年多器官疾病杂志》2010年第5期425-427,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的通过检测急性冠状动脉综合征(ACS)患者血清中1型辅助性T细胞/2型辅助性T细胞(Th1/Th2)细胞因子的变化,探讨细胞因子变化在斑块活化和进展评估中的作用。方法 ACS患者64例,其中急性心肌梗死22例,不稳定型心绞痛42例,同时选取稳定型心绞痛患者34例及正常对照22例。测定血清中的γ干扰素(IFN-γ)、白细胞介素-2(IL-2)I、L-4和IL-10水平,所有患者均行冠脉造影检查。结果 ACS患者外周血Th1细胞因子水平明显高于、而Th2细胞因子水平则明显低于正常对照组和稳定型心绞痛组。依据冠脉斑块形态分为两型,Ⅱ型斑块患者血清中的Th1细胞因子水平显著高于Ⅰ型斑块患者;Ⅱ型斑块患者Th2细胞因子显著低于Ⅰ型斑块患者。结论外周血中Th1/Th2细胞因子水平的失衡与ACS的发生密切相关,对斑块的活化和进展有一定的量化评估作用。Objective To evaluate the change in Th1/Th2 related cytokines in the peripheral blood of patients with acute coronary syndrome（ACS）,and to determine its roles in assessing the development of the lesion.Methods Sixty-four ACS patients were selected,including 22 patients with acute myocardial infarction（AMI）,and 42 patients with unstable angina pectoris（UAP）.Another 34 patients with stable angina pectoris（SAP） and 22 healthy persons served as controls.Serum concentrations of Th1/Th2 cytokines,such as IFN-γ,IL-2,IL-4,and IL-10 were measured.All patients underwent coronary angiography（CAG）.Results The level of Th1 cytokines,including IFN-γ and IL-2,was elevated in patients with UAP and AMI compared to that with SAP and healthy controls.The level of Th2 cytokines,including IL-4 and IL-10,was decreased in patients with UAP and AMI compared to that with SAP and healthy controls.Compared with the type Ⅰ lesion,patients with type Ⅱ lesions showed higher in-gate percentage of Th1 cytokines and lower in-gate percentage of Th1 cytokines.Conclusion The imbalance of Th1/Th2 cytokines is correlated with the development of ACS,which could be useful for monitoring the stabilization of the lesion.

关 键 词：细胞因子 辅助性T细胞 急性冠状动脉综合征 

分 类 号：R543.3[医药卫生—心血管疾病]