生殖道B族溶血性链球菌、支原体和沙眼衣原体感染与胚胎发育停止的关系  

Relationship between the Colonization of Group B Streptococci,Mycoplasma,and Chamydia Trachomatis Infections and Spontaneous Abortion Due to Early Embryonic Death

作　　者：李永红[1] 吴钦兰[1] 邹一梅[1] 潘伟芳[1] 彭丹[1] 刘欣燕[2] 

机构地区：[1]广州医学院附属深圳沙井医院妇产科,广东深圳518104 [2]中国医学科学院北京协和医学院北京协和医院妇产科,北京100730

出　　处：《中国医学科学院学报》2010年第5期513-515,共3页Acta Academiae Medicinae Sinicae

基　　金：深圳市宝安区科技立项(2009379)~~

摘　　要：目的研究生殖道B族溶血性链球菌(GBS)、支原体和沙眼衣原体(CT)感染与胚胎发育停止之间的关系。方法以74例孕早中期胚胎发育停止的患者(研究组)和62例孕早中期正常妊娠引产患者(对照组)为研究对象,采集阴道分泌物、宫腔内吸出物和羊水标本进行GBS培养,同时检测宫颈支原体和CT。结果研究组和对照组阴道分泌物GBS培养阳性率分别为12.16%(9/74)和9.68%(6/62),差异无统计学意义(P=0.662);所有患者的宫腔内吸出物或羊水GBS培养均为阴性。研究组解脲支原体和人型支原体培养的阳性率分别为32.43%(24/74)和16.22%(12/74),明显高于对照组的10.35%(12/62)(P=0.0103)和6.45%(4/62)(P=0.042)。研究组和对照组的CT阳性率分别为8.11%(6/74)和8.06%(5/62),差异无统计学意义(P=0.905)。研究组和对照组GBS合并支原体感染率分别为4.05%(3/74)和6.45%(4/62),差异无统计学意义(P=0.743);GBS合并CT感染率分别为0和1.61%(1/62),差异无统计学意义(P=0.475);支原体合并衣原体感染率分别为2.70%(2/74)和0,差异无统计学意义(P=0.325);3种病原体合并感染率均为0。结论部分妊娠妇女生殖道可携带GBS,但与胚胎发育停止无关。支原体感染可能是导致胚胎发育停止的原因之一。Objective To explore the relationship between the colonization of group B streptococci（GBS）,mycoplasma,and Chlamydia trachomatis（CT）infections and spontaneous abortion due to early embryonic death.Methods Totally 74 patients（study group）who experienced the missed abortion during their first or second trimester and 62 women（control group）who underwent induced termination of normal pregnancyduring the first or second trimester were enrolled in this study.The vaginal secretions,intrauterine aspirates,and amniotic fluids were collected for GBS culture.Cervical mycoplasma（UU＋MH）and CT were detected at the same time.Results Positive results of GBS culture of vaginal secretions were detected in 9 patients（12.16%）in the study group,but in only 6 patients（9.68%）in control group（P=0.662）.The intrauterine aspirate samples（as well as the amniotic fluid samples）of all cases were negative in GBS culture.The positive rates of UU and MH were 32.43%（24/74）and 16.22%（12/74）in the study group,but were only 10.35%（12/62）（P=0.0103）and 6.45%（4/62）（P=0.042）in the control group.The positive rate of CT was 8.11%（6/74）in the study group and 8.06%（5/62）in the control group（P=0.905）.The rate of concurrent infection of GBS and mycoplasma was 4.05%（3/74）in the study group and 6.45%（4/62）in the control group（P=0.743）.The rate of concurrent infection of GBS and CT was 0 in the study group and 1.61%（1/62）in the control group（P=0.475）.The rate of concurrent mycoplasma and CT infection was 2.70%（2/74）in the study group and 0 in the control group（P=0.325）.Furthermore,no one was positive for polyinfection of all these three pathogens.Conclusions GBS may be positive in the genital tract of some pregnant women but is not related with early abortion.The mycoplasma infection may be one of the reasons leading to arrested intrauterine pregnancy.

关 键 词：B族溶血性链球菌 支原体 衣原体 感染 自然流产 

分 类 号：R714.2[医药卫生—妇产科学]