维生素D3衍生物治疗白癜风的研究现状  

Vitamin D3 analogs for the treatment of vitiligo

作　　者：李湘君[1] 李其林[1] 

机构地区：[1]暨南大学第四附属医院暨广州市红十字会医院,广州510220

出　　处：《国际皮肤性病学杂志》2010年第6期316-319,共4页International Journal of Dermatology and Venereology

基　　金：广东省自然科学基金（9151051501000006）

摘　　要：维生素D3活性代谢产物1,25（OH）2D3及其衍生物通过其细胞核受体维生素D受体发挥重要的生理作用,除了经典的调节钙、磷代谢外,1,25（OH）2D3及其衍生物抗增殖及促分化的免疫调节作用正在被逐渐认识.它可能通过调节皮肤局部的免疫反应、促进黑素生成、抗氧化应激、抗细胞凋亡及修复体内钙稳态的作用来保护表皮黑素单位,减少黑素细胞的破坏,从而有效地治疗白癜风.因此,进一步了解维生素D3衍生物在白癜风复色中的作用机制,对于更有效地治疗白癜风具有重要的意义.The active metabolite of vitamin D3 [1,25 （OH）2D3] and its analogs exert important physiological roles through its nuclear receptor （VDR）. Besides regulating the metabolism of calcium and phosphorus, 1,25-（OH）2D3 and its synthetic analogs have been increasingly recognized for their immunomodulatory potential to inhibit proliferation and promote differentiation of cells. They can effectively treat vitiligo by protecting skin melanin units and deccelarating the destruction of melanocytes, likely via modulating local immune response in skin, promoting melanogenesis, counteracting oxidative stress and apoptosis, and restoring impaired calcium homeostasis. Therefore, to further understand the mechanism of vitamin D3 analogs in the repigmentation of vitiligo may be substantially beneficial for the effective treatment of vitiligo.

关 键 词：白癜风 胆骨化醇 治疗 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]