鼠伤寒沙门菌L型变异对噬菌体敏感性的影响  

Effect on phage sensitivity resulting from the Lformsvariation of Salmonella typhimurium

作　　者：胡志荣[1] 骆卫锋[1] 苏堤[1] 胡军[1] 赵凤兰[1] 徐友梅[1] 

机构地区：[1]河南医科大学微生物学与免疫学教研室

出　　处：《河南医学研究》1999年第2期122-123,共2页Henan Medical Research

摘　　要：目的：探讨鼠伤寒沙门菌的Ｌ型变异对噬菌体敏感性的影响。方法：用１２株鼠伤寒沙门菌分型噬菌体对３株体外诱导的鼠伤寒沙门菌Ｌ型及其原菌做噬菌体敏感性检测。结果：裂解原菌的噬菌体大多不能裂解其Ｌ型菌，只有少数噬菌体能同时裂解原菌及其Ｌ型菌。结论：鼠伤寒沙门菌的Ｌ型变异可引起噬菌体受体的丢失，从而导致对相应的噬菌体不再敏感。Objective: To investigated the effect on phage sensitivity resulting from the Lforms variation of Salmonella typhimurium. Methods: Phage sensitivity of 3 strains of Salmonella typhimurium Lforms induced in vitro and their parents were tested by 12 strains of typing bacteriophages of Salmonella typhimurium. Results: Most bacteriophages which could lysis the parental Salmonella typhimurium could not lysis their Lforms.Only few bacteriophages could lysis both the Lforms and their parents.HX]Conclusion: The Lforms variation of Salmonella typhimuium could induce the loss of bacteriophage receptors,consequently the Lforms were resistant to the parental bacteriophages.

关 键 词：鼠伤寒沙门菌 细菌L型 噬菌体 分型 

分 类 号：R378.23[医药卫生—病原生物学]