136例慢性排菌肺结核临床药敏结果分析  

The analysis of drug susceptibility results of 136 refractory tuberculosis

作　　者：高三友[1] 陈瑛[1] 赵玉玲[1] 

机构地区：[1]河南省胸科医院

出　　处：《河南医学研究》1999年第2期154-155,共2页Henan Medical Research

摘　　要：目的：了解难治性肺结核的耐药特征，为结核病防治提供参考依据。方法：改良罗氏培养基绝对浓度法。结果：１３６例慢性排菌肺结核病人分别对两种或以上主要抗结核药物耐药，其综合耐药率为１００％，其中以耐链霉素、利福平及异烟肼为主，乙胺丁醇、卡那霉素次之，对氟嗪酸也有一定程度的耐药性。结论：对慢性排菌病人的治疗应认真参考药敏结果，慎重选择敏感的药物组合治疗方案，不宜机械地制定“统一”的化疗方案，尽可能避免敏感药物的继发性耐药。Objective: To probe the susceptibility character of refractory tuberculosis into drug, so as to provide the reference for prevention and cure of tuberculosis. Methods: Absolute density method by improved LJ culture. Resluts : The acquired resistance rate of 136 refractory tuberculosis is 100%. They have leastwise ressisted two drug or more among INH, RFP, EMB, SM etc. Conclusion: It is necessary that the drug should be selected according to the sensitivity test reslts for treatment of refractory tuberculosis. It is not fit to constitute automatically a same chemistry therapy scheme for refractory tuberculosis. No other th an effective and reasonable therapy can promote the tuberculosis epidemic situation to drop down quickly.

关 键 词：肺结核 药物耐受性 多种耐药性 

分 类 号：R521.05[医药卫生—内科学] R969.4[医药卫生—临床医学]