MicroRNA研究进展  

The Research Progress of MicroRNA

作　　者：赵奎[1] 庞全海[1] 

机构地区：[1]山西农业大学动物科技学院,太谷030801

出　　处：《生物技术通报》2010年第12期7-11,共5页Biotechnology Bulletin

基　　金：国家自然科学基金项目(30972223);山西农业大学基金项目(412528;614114)

摘　　要：MicroRNA(miRNA)是生物体内源长度约为21-25个核苷酸的非编码小RNA,通过与靶mRNA互补配对而在转录水平上对基因的表达进行负调控,导致mRNA的翻译抑制或降解。miRNA虽然微小,但它在真核生物发育和基因表达中通过与靶mRNA形成完全或不完全互补配对从而扮演着重要角色。它们参与动物体发育、细胞增殖与死亡、细胞分化等各种过程。综述了miRNA的发现、生物合成、特征与功能、靶基因的预测等方面的研究进展。MicroRNA（miRNA）are a class of endogenous noncoding single-stranded RNA with about 21-25 nucleotides length.MicroRNA function as sequence-specific negative regulators in post-transcriptional gene silencing by base pairing with target mRNAs,which leads to mRNA cleavage or translational repression.Although they are tiny,in eukaryotes,microRNA play important roles in gene expression regulation,typically by forming perfect or imperfect duplexes with target messenger RNAs.These miRNA are involved in physical development,death proliferation,and differentiation of cell.This review tries to have a brief introduction on the progresses of miRNA study,such as the discovery,biogenesis,feature and functions,and gene prediction.

关 键 词：MIRNA 生物学功能 靶基因预测 

分 类 号：Q75[生物学—分子生物学]