STAT5a和STAT5b蛋白在非小细胞肺癌中的表达及临床意义  

Clinical significance of the expression of STAT5a,STAT5b in Human non small cell lung cancer

作　　者：侯莉莉[1] 王乐朋[1] 胡福英[1] 王鸿程[2] 

机构地区：[1]河北省胸科医院,石家庄050041 [2]四川省泸州医学院附属医院呼吸内科,泸州646000

出　　处：《中国免疫学杂志》2010年第11期1029-1032,共4页Chinese Journal of Immunology

基　　金：四川省科技厅重点基金项目(2006J13-92)

摘　　要：目的:探讨信号转导和转录激活因子-5a(STAT5a)和信号转导和转录激活因子-5b(STAT5b)在非小细胞肺癌(NSCLC)中的表达及意义。方法:用免疫组化SP法检测40例手术切除的NSCLC和20例正常肺组织中STAT5a和STAT5b的表达。结果:STAT5a和STAT5b在NSCLC中的表达明显高于正常肺组织(P<0.01),STAT5a和STAT5b的表达与患者的年龄、肿瘤大小、组织分化程度及组织类型、淋巴结转移及TNM分期等病理因素无关。在NSCLC中,STAT5b与患者的性别有相关性(P<0.05),其中女性患者表达高于男性患者(P<0.05)。STAT5a与NSCLC中关系比STAT5b密切,在NSCLC的发生中,STAT5a和STAT5b蛋白表达没有相关性。结论:STAT5a和STAT5b蛋白可能促进NSCLC的形成,但与肿瘤的进展可能无关,STAT5b蛋白与性别有一定的相关性。在NSCLC的发生过程中,STAT5a与STAT5b蛋白可能是各自独立发挥作用的,无协同作用。STAT5a在NSCLC的发生中发挥的作用可能更大。Objective：To investigate the expression of STAT5a,STAT5b in non small cell lung cancer（NSCLC）and its clinical significance.Methods：40 cases of NSCLC tissues were detected with immunohistochemical staining（SP）,20 cases with normal pulmonary tissues as control.Results：There was significant diference of STAT5A and STAT5b expressions between NSCLC and normal pulmonary tissues（P〈0.01）.Both STAT5a and STAT5b had no significant association with the age of patients,tumor diameter,lymph node metastasis,histological differentiation and grading in NSCLC.STAT5b had a certain of correlation with the sex of patients（P〉0.05）.The expression of female patients was higher than in male patients（P〈0.05）.The overexpression of STAT5a may be play a role in NSCLC.There was not significant correction between STAT5a and STAT5b expression in NSCLC.Conclusion：STAT5a and STAT5b are overexpressed in human NSCLC,but there is no correlation between their overexpression and these clinico-pathological factors.but STAT5b has a certain of correlation with sex of patients.STAT5a and STAT5b might have no synergistic action with each other in NSCLC.STAT5a may play a role in NSCLC.

关 键 词：STAT5a STAT5B 非小细胞肺癌 

分 类 号：R392.11[医药卫生—免疫学]