甘草酸二铵治疗急性重症病毒性心肌炎疗效观察  

Observation on the Effect of Diammonni Glycyrrhizinatis in the Treatment of Serious Type of Acute Virus Myocarditis

作　　者：马路[1] 葛金波[2] 朱晓法[1] 王显[3] 王忠卯[4] 赵美娜[1] 李明强[4] 韦红霞[4] 

机构地区：[1]中国人民解放军海军总医院干一科,北京100048 [2]新疆军区门诊部,乌鲁木齐833002 [3]北京军区总医院心内科,北京100700 [4]中国人民解放军第15医院,新疆乌苏833000

出　　处：《中国现代应用药学》2010年第10期958-960,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的观察甘草酸二铵对急性重症病毒性心肌炎的临床疗效。方法将69例住院治疗的急性重症病毒性心肌炎患者随机分为治疗组(37例)与对照组(32例),对照组采用常规治疗加地塞米松,治疗组在常规治疗基础上加用甘草酸二铵注射液静脉输注,疗程结束后观察两组患者的临床症状、心电图、心肌损伤标志物等变化。结果治疗组临床疗效总有效率为89.19%,心电图总有效率为91.89%,心肌损伤标志物改善总有效率为94.59%;对照组临床疗效总有效率为65.63%,心电图总有效率为71.88%,心肌损伤标志物改善总有效率为75%,治疗组疗效均优于对照组(P<0.05)。结论甘草酸二铵注射液治疗急性重症病毒性心肌炎可使临床疗效提高。OBJECTIVE To observe the treatment effect of diammonni glycyrrhizinatis on serious type of acute virus myocarditis.METHODS The 69 patients with serious type of acute virus myocarditis were divided into two groups randomly.The treatment group of 37 patients were treated by venous transfusion of diammonni glycyrrhizinatis 150 mg per day for 2 weeks while the control group was treated by venous transfusion of dexamethasone 5 mg per day for 2 weeks.The symptom,electrocardiography,myocardial injury marker were measured before and after treatment.RESULTS The rate of electrocardiography,myocardial injury marker normalization,and clinical treatment effect in the treatment group were 91.89%,94.59%,and 89.19%,respectively;while in the control group,they were 71.88%,75% and 65.63%.CONCLUSION The treatment of diammonni glycyrrhizinatis on serious type of acute virus myocarditis can elevate clinical effect.

关 键 词：病毒性心肌炎 甘草酸二铵 心肌损伤 

分 类 号：R282.77[医药卫生—中药学] R286[医药卫生—中医学]