四种新型仲胺配合物的合成、表征及与ct-DNA相互作用的光谱研究  

Synthesis,Characterization and Interaction with ct-DNA of Four Novel Secondary Amine Complexes

作　　者：刘娜[1] 贾春满[1] 张岐[1,2] 袁文兵[1] 戴雪芹[1] 吴静波[2] 

机构地区：[1]海南大学,海南省精细化工重点实验室,海南海口570228 [2]江苏大学化学化工学院,江苏镇江212013

出　　处：《光谱学与光谱分析》2010年第12期3343-3346,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(20871061);海南大学奖励基金项目(hd09xm07/24);海南省自然科学基金项目(209001)资助

摘　　要：合成了新型仲胺类配体L(N,N’-二(4-甲基苄基)乙二胺)及其四种过渡金属的硝酸盐配合物,[ML2(H2O)2]2+.2NO3-(M=CuⅡ,CoⅡ,NiⅡ,ZnⅡ),利用元素分析、红外、1H NMR等对其结构进行了表征,其中用X-ray单晶衍射解析了Cu-L单晶结构,为波谱分析推测的分子结构进行了验证。通过紫外、荧光光谱研究了该四种金属配合物与小牛胸腺DNA的相互作用,结果表明配合物与DNA的作用方式均为静电结合,Cu-L,Co-L,Ni-L,Zn-L与DNA的结合常数分别为:1.67×103,2.5×103,1.35×103和9.85×102。A novel ligand（L）,（N,N＇-bis（4-methylbenzyl）ethane-1,2-diamine）,and its transition metal（Ⅱ） complex,[ML2（H2O）2]2＋·2NO-3（M=CuⅡ,CoⅡ,NiⅡ,ZnⅡ）,have been synthesized and characterized by elemental analysis,IR and 1H NMR.The crystal structure of the Cu-L complex was characterized by X-ray single crystal diffraction,and the results showed a regular octahedral structure in which each metal ion is six–coordinated with four nitrogen atoms from two ligands and two oxygen atoms from two water molecules. The interaction of the complex with calf thymus DNA was investigated by UV spectroscopy and fluorescence spectroscopy,and the results suggest that the complex binds to DNA by electrostatic interaction mode.The binding constant（Cu-L,Co-L,Ni-L,Zn-L） was 1.67×103,2.5×103,1.35×103 and 9.85×102,respectively.

关 键 词：DNA 相互作用 配合物 过渡金属 单晶结构 

分 类 号：O644.1[理学—物理化学]