PTEN蛋白在人脑星形细胞肿瘤中的表达及其意义  

Expression and significance of PTEN protein in brain astrocytoma

作　　者：吴永刚[1] 吴红星[1] 郑勇[1] 杨小朋[1] 

机构地区：[1]新疆维吾尔自治区人民医院神经外科,新疆乌鲁木齐830001

出　　处：《农垦医学》2010年第3期208-210,共3页Journal of Nongken Medicine

摘　　要：目的：探讨PTEN蛋白在不同分化程度的星形细胞肿瘤组织中的表达。方法：应用S-P免疫组化技术检测46例星形细胞肿瘤中PTEN蛋白的表达。结果：脑星形细胞肿瘤组织中PTEN蛋白的阳性表达率为63.4%,低分化（Ⅲ~Ⅳ级）星形细胞肿瘤组织中PTEN蛋白的阳性表达显著低于高分化（Ⅰ~Ⅱ级）星形细胞肿瘤（p〈0.01）;且病理分级与PTEN蛋白的阳性表达呈负相关（r=-0.612,p〈0.01）。结论：PTEN基因表达缺失与脑星形细胞肿瘤的分化程度与演进密切相关。Objective：To investigate PTEN protein expression in brain astrocytoma with various grades.Methods：Expression of PTEN protein was studied by immunohistochemical staining in 46 cases of astrocytoma.Results：The positive rate of PTEN protein was 63.4% in astrocytoma;The positive rates decreased with progression of pathological grade（p0.01）;The pathological grade was associated with PTEN protein expression in astrocytoma（r=-0.612,p0.01）.Conclusion：PTEN gene mutation and deletion play a key role in astrocytoma pathogenesis and progression;PTEN expression is closely correlated to tumor differentiation in astrocytoma.

关 键 词：PTEN蛋白 星形细胞肿瘤 免疫组化 

分 类 号：R34[医药卫生—基础医学]