帕罗西汀与氯丙咪嗪治疗强迫症的临床对照研究  

Paroxetine vs.Clomipramine for Obsessive-compulsive Disorder:A Clinical Control Study

作　　者：范毅[1] 安震[1] 

机构地区：[1]天津市公安局安康医院,天津300240

出　　处：《中国医院用药评价与分析》2010年第11期1021-1022,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察并对比帕罗西汀和氯丙咪嗪治疗强迫症患者的疗效和不良反应。方法:以CCMD-3作为诊断标准,选取强迫症患者100例,随机分为2组,分别用帕罗西汀和氯丙咪嗪治疗8周。应用Yale-Brown强迫量表(Y-BOCS)、汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)及临床4级标准评定疗效,用副反应量表(TESS)评定不良反应。在治疗前及治疗后4、8周末,分别评定临床疗效、以上量表的分数及不良反应。结果:帕罗西汀与氯丙咪嗪两组患者疗效的差异无显著性(P>0.05);帕罗西汀不良反应明显少于氯丙咪嗪(P<0.01),而且耐受性好。结论:帕罗西汀治疗强迫症的疗效与氯丙咪嗪相当,但帕罗西汀具有日剂量小、给药简单方便、不良反应比氯丙咪嗪少而轻等优点。OBJECTIVE：To observe the curative effect and side effects of paroxetine vs.clomipramine in the treatment of obsessive-compulsive disorder.METHODS：60 patients with obsessive-compulsive disorder meeting the CCMD-3 diagnostic criteria were randomly assigned to receive either paroxetine or clomipramine for 8 weeks.YaleBrown Obsessive-compulsive Scale（Y-BOCS）,Hamilton Depression Scale（HAMD）,Hamilton Anxiety Scale（HAMA） and the clinical 4-grade criteria were used to evaluate the clinical efficacy;and the Treatment Emergent Symptom Scale（TESS） was employed to evaluate the side effects at study entry and at the end of weeks 4 and 8 of treatment.RESULTS：There was no significant difference in clinical efficacy between the two groups（P 〉 0.05）.Paroxetine showed significantly less side effects than did clomipramine（P 〈 0.01） and good drug tolerability.CONCLUSION：Paroxetine is as effective as clomipramine yet with less daily dose,simple administration and less side effects in the treatment of obsessive-compulsive disorder.

关 键 词：帕罗西汀 氯丙咪嗪 强迫症 

分 类 号：R971[医药卫生—药品]