乌司他丁在重型颅脑损伤围手术期应用的研究  

Study of perioperative application of ulinastatin in severe craniocerebral injury patients

作　　者：卿帅[1] 田凯[2] 吴柯[3] 张努[4] 周力平[1] 

机构地区：[1]四川省宜宾市第一人民医院麻醉科,四川宜宾644000 [2]成都医学院附属宜宾医院,四川宜宾644000 [3]四川省宜宾市第一人民医院神经外科,四川宜宾644000 [4]四川省宜宾市第一人民医院ICU,四川宜宾644000

出　　处：《吉林医学》2010年第32期5717-5718,共2页Jilin Medical Journal

摘　　要：目的:探讨乌司他丁对重型颅脑损伤的治疗效果及对患者远期预后的影响。方法:重型颅脑损伤患者67例,随机分为观察组和对照组,均给予常规治疗,观察组给予乌司他丁治疗7d。记录患者入院当日及术后3、7、14d的GCS评分,神经源性肺水肿(NPE)、应激性溃疡的发生概率。结果:与对照组比较观察组GCS评分更高,应激性溃疡及神经源性肺水肿等并发症的发生率明显降低。结论:乌司他丁能够有效地治疗重型颅脑损伤,并可降低其并发症。Objective To investigate the therapeutic effects of ulinastatin for severe craniocerebral injury and the influence on long-term prognosis.Method Sixty-seven patients causing severe craniocerebral injury were divided into two groups randomly.Patients in the control group were given conventional treatment;patients in the observing group were given ulinastatin for 7 days on the basis of conventional treatment.GCS,incidence of NPE and stress ulcer were observed on 0,3,7 and 14 days after operation.Results Compared with the control group,the observing group had much higher GCS score and lower incidence of NPE and stress ulcer.Conclusion Ulinastin can treat severe craniocerebral injury effectively and decrease complications.

关 键 词：重型颅脑损伤 乌司他丁 应激性溃疡 并发症 

分 类 号：R651.1[医药卫生—外科学]