电磁脉冲对大鼠学习和脑内神经递质的影响  

INFLUNECE OF EMP ON THE NERVOUS SYSTEM OF RATS

作　　者：吴彦卓[1] 贾宇峰[1] 郭鹞[1] 郑振兴[2] 

机构地区：[1]第四军医大学放射医学教研室 [2]西北核技术研究所

出　　处：《生物物理学报》1999年第1期152-157,共6页Acta Biophysica Sinica

摘　　要：探讨电磁脉冲（ＥＭＰ）对大鼠神经系统的效应。实验采用Ｗｉｓｔａｒ大鼠，ＥＭＰ辐照后不同时间用Ｙ－型迷宫测其学习能力，高效液相色谱法检测脑不同部位的神经递质含量。与假照射组（对照组）相比，照后三天内各测定组大鼠学习能力降低（Ｐ＜０．０５），其中照射后第１天组的海马内５－羟色胺（５－ＨＴ）和多巴酸（ＤＯＰＡＣ）含量升高（Ｐ＜０．０５），下丘脑多巴胺（Ｄｏｐａｍｉｎｅ）含量升高（Ｐ＜０．０５），肾上腺素（Ａｄｒ）含量降低；照后２天组海马Ａｄｒ含量降低（Ｐ＜０．０５），海马５－ＨＴ含量升高（Ｐ＜０．０５）；照后３天组海马内Ａｄｒ含量降低（Ｐ＜０．０５）。ＥＭＰ能够改变大鼠不同脑区神经递质的含量。To explore the effects of Electromagnetic pulse (EMP) exposure on the nervous system of rats. The Wistar rats were divided into four groups: three exposure groups and one normal control group. The measurement of ability of learning of rats was carried with Y-maze, followed by the detection of the content of neurotransmitters in different areas of cerebrum. Compared with control group, in the following three days of EMP exposure, the ability of learning of exposure groups decreased (P<0.05). For one day group, in hippocampus, the content of 5-HT and DOPAC increased (P<0.05), and in hypothalamus, the content of Dopamine increased (P<0.05), whilethe content of Adr decrease ( P<0.05). The content of Adr and 5-HT in hippocampus of the second day group reduced (P<0.05). The content of Adr in hippocampus of the third day group was still lower than that of control group (P<0.05). According to the results above, we can conclude that EMP exposure results in changes of the content of neurotransmitters in different cerebral areas of rats, lowering their ability of learning.

关 键 词：电磁脉冲 神经系统 效应 学习 神经递质 

分 类 号：Q691.5[生物学—生物物理学]