滇产胡椒属植物醇提物抗血小板活性研究  

STUDY ON ANTIPLATELET ACTIVITY OF ALCOHOL EXTRACTS FROM PIPER SPECIES NATIVE TO YUNNAN

作　　者：沈志强[1] 陈植和[1] 段理[2] 

机构地区：[1]云南省天然药物药理重点实验室,昆明医学院昆明650031 [2]昆明医学院第一附属医院,影像学科昆明650032

出　　处：《天然产物研究与开发》1999年第2期27-31,共5页Natural Product Research and Development

基　　金：云南省应用基础研究基金资助项目

摘　　要：采用Born氏比浊法观察了12种滇产胡椒属植物的乙醇提取物对血小板活化因子(PAF)、花生四烯酸(AA)和二磷酸腺苷(ADP)引起血小板活化聚集的影响.结果表明,这12种醇提物均明显抑制PAF诱导的血小板聚集,其中部分醇提物对AA和ADP引起的聚集亦有显著拮抗作用.结果提示。Born's method was used to determine the effects of 12 alcohol extracts from Piper species indigenous to Yunnan Province on platelet activating factor(PAF) ,arachidonic acid(AA)or adenosine diphosphate(ADP)-induced platelet aggregation. The results showed that these 12 alcohol extracts significantly inhibited PAF-induced platelet aggregation; some of them markedly suppressed platelet aggregation induced by AA or ADP. It is demonstrated that these 12 alcohol extrcats showed powerful antiplatelet activity.

关 键 词：胡椒属 血小板聚集 血小板活化因子 

分 类 号：R285.5[医药卫生—中药学]