毁损弓状核对动脉粥样硬化形成的影响  

INFLUENCE OF THE ARCUATE NUCLEUS DAMAGED BY MONOSODIUM GLUTAMATE ON THE DEVELOPMENT OF ATHEROSCLEROSIS

作　　者：吴开云[1] 高摄渊[2] 

机构地区：[1]江西医学院解剖学教研室,南昌330006 [2]组织学与胚胎学教研室,南昌330006

出　　处：《神经解剖学杂志》1999年第1期79-81,共3页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金!No.39660031

摘　　要：本实验分为四组：（1）单纯毁损弓状核组，（2）毁损弓状核＋动脉粥样硬比诱发剂组，（3）单纯给予动脉粥样硬化诱发剂组和（4）对照组，包括腹腔注射生理盐水及皮下注射谷氨酸单钠等2组。在通过电镜观察主动脉壁变化的同时探讨下丘脑弓状核对动脉粥样硬化形成的影响。结果发现：单纯毁损弓状核组血管内皮细胞明显变性，细胞核肿胀，内皮下层增厚并出现空泡，可见有平滑肌细胞向内皮下层迁移，形成明显的动脉粥样硬化早期病变；毁损弓状核＋动脉粥样硬化诱发剂组和单纯用动脉粥样硬化诱发剂组，血管壁的变化基本与单纯毁损弓状核组相同，都有内皮细胞变性，细胞核肿胀，内皮下层增厚和出现空泡等变化，与单纯毁损弓状核组相比未发现有明显不同的变化；对照组未发生任何病理变化。本研究提示下丘脑弓状核对动脉粥样硬化的形成可能有直接调控作用。The animals were divided into 5 groups: (1) new born rats With arcuate nucleus damaged by monosodium glutamate(MSG); (2) new born rats with the same treatment as (1) and induced atherosclerosis by Vitamin D(VD); (3) 10 week ratswith induced atherosclerosis by VD only; (4) 10-week rats with intraperitoneal injection of normal saline; (5) 10-week rats with,hypodermal injection of MSG. Group (4) and (5) were used for control. Specimens from thoracic and abdominal aorta were taken for observation under electron microscope. The results showed that in group (1) (arcuate nucleus damaged by MSG), degeneration of endothelial cells could be seen and the nuclei of the endothelial cells become edematous. There were vesicles of varioussizes in subendothelial tissue. and smooth muscle cells migrated from tunica media to tunica intima through the ruptured elastieainterna. These changes showed an early sign of atherosclerosis. The changes in group (2) and (3) were similar when comparedwith those of arcuate nucleus damaged by MSG group. The structure of the aorta in control groups remained intact. This studyindicates that hypothalamic arcuate nucleus damage might be relaied to the development of atherosclerosis.

关 键 词：动脉粥样硬化 弓状核 毁损 病理学 

分 类 号：R543.502[医药卫生—心血管疾病]