锌离子与Aβ多肽中氨基酸结合能力次序的研究  

Research on the Sequence of Binding Ability between Zinc Ion with Amino Acids in Aβ Peptide

作　　者：张朝峰[1] 袁兵兵[1] 张照昱[1] 李彦威[1] 

机构地区：[1]太原理工大学化学化工学院,太原030024

出　　处：《太原理工大学学报》2010年第6期737-739,共3页Journal of Taiyuan University of Technology

基　　金：国家自然科学基金资助项目(30470408)

摘　　要：阐明金属离子的稳态失衡是导致老年痴呆病人脑部Aβ多肽发生聚集的因素之一,金属离子与Aβ多肽的结合位点是开发靶向药物的关键所在。采用紫外分光光度法,首次对生理条件下锌离子与Aβ多肽中氨基酸的络合作用进行了研究,得到了该条件下络合物的稳定常数大小,指出了锌离子-Aβ多肽可能的结合位点,这一结果对深入了解金属离子在诱导老年痴呆过程中的协同作用以及金属螯合剂药物治疗提供实验支持。The imbalance of metal ions can lead to the gathering of Aβ peptide in the brains of AD,and the binding site between metal ions and Aβ peptide is the key to develop targeting drugs.In this paper,UV spectrophotometry was used to researsch the complex role between amino acids in the Aβ peptides with zinc-Ⅱ under physiological conditions for the first time,the stability constant was a obtain the possible binding site of zinc-Aβ peptides was pointed out.The results can provide experimental support for both understanding the synergies of metal ions in the Alzheimer＇s course and metal chelate drug treatment.

关 键 词：老年痴呆症 Aβ多肽 锌离子 稳定常数 

分 类 号：Q516[生物学—生物化学] O614.2[理学—无机化学]