复方氟米松联合维A酸霜治疗毛孔角化症探讨  

Treatment of keratosis pilaris with compound flumetasone ointment and tretinoin cream

作　　者：郭猛[1] 徐春华[1] 

机构地区：[1]河南省商丘市第一人民医院皮肤性病科,476100

出　　处：《中国医药》2010年第12期1184-1185,共2页China Medicine

摘　　要：目的 研究复方氟米松软膏联合维A酸霜治疗毛孔角化症的临床疗效及安全性.方法 采用随机双盲对照的分析方法,将入选98例毛孔角化症患者完全随机分为治疗组和对照组,各49例.治疗组接受复方氟米松软膏联合维A酸霜联合外用治疗,对照组单纯应用维A酸霜外用治疗,4周为1个疗程,2个疗程后判定疗效.结果 2个疗程后,治疗组总有效率为89.8%（44/49）.对照组有效率为73.5%（36/49）,P＜0.05,两组比较,差异有统计学意义x2=4.36.治疗组有2例、对照组有7例出现轻微不良反应,主要表现为局部皮肤红斑、灼痒、脱屑,暂停用药后自然缓解.2组的不良反应发生率分别为4.1%和14.3%,差异有统计学意义（P＜0.05）.治疗组优于对照组.结论 复方氟米松软膏联合维A酸霜治疗毛孔角化症安全有效.Objective To study the efficacy and safety of Compound Flumetasone Ointment and Tretinoin Cream in the treatment of keratosis pilaris. Methods The random double-blind contrast was adapted. The cases were divided into 2 groups randomly： the treatment group received compound flumetasone ointment and tretinoin cream; the control group received only tretinoin cream. Results After two courses of treatment, the efficiency of treatment group and control group was 89. 8% and 73.5% respectively （x2 = 4. 36,P 〈 0. 05）. Conclusion The treatment of keratosis pilaris with compound flumetasone ointment and tretinoin cream is safe and valid.

关 键 词：角化病 氟米松 维A酸 

分 类 号：R751[医药卫生—皮肤病学与性病学]