^(123)I-MIBG的制备及动物实验研究  

Preparation of ^(123)I-MIBG and Animal Experiment

作　　者：陈宝军[1] 陈大明[1] 杨红伟[1] 梁积新[1] 邓雪松[1] 赵贵植[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413

出　　处：《原子能科学技术》2010年第11期1299-1302,共4页Atomic Energy Science and Technology

摘　　要：采用亚铜离子催化法制备123I-MIBG,对其制备条件进行了优化,并研究了所制备的123I-MIBG在常温下存放的稳定性以及在正常小鼠体内的生物分布情况。采用优化后的标记条件,123I-MIBG的标记率可达95%以上,制得的不同浓度和比活度的123I-MIBG室温下至少可稳定存放48h以上,显示出其良好的体外稳定性。体内生物分布数据显示:123I-MIBG在肾上腺有最高的摄取(6.18±1.01)%ID·g-1,且在48h内一直保持着较强的吸收;在心、肝、脾、肺、胃肠中也均有一定的摄取,但在血中的摄取量较低。123I-MIBG在组织内的吸收与代谢趋势与文献报道结果相一致。Metaiodobenzyl guanidine（MIBG）was labeled with ^123I using the catalyst of cuprous.The stability in vitro at atmospheric temperature and the biodistribution in normal mouse of ^123I-MIBG were studied.The labeling yield is over 95%at optimizing labeling conditions.The prepared ^123I-MIBG shows high stability after incubating at room temperature for over 48hwith different radioactive concentrations and specific activities.The highest uptake of ^123I-MIBG with（6.18±1.01）%ID·g^-1 is found in adrenals 1hafter injection according to the result of in vivo biodistribution in mouse. There are uptake in heart,lung,kidney and intestine,but the uptake in blood is low. The biodistribution and metabolism of ^123I-MIBG are accordance with reported results.

关 键 词：123I-MIBG 放射性标记 生物分布 

分 类 号：TL817.2[核科学技术—核技术及应用]