咽炎方含片的醇沉工艺优化  

Optimization of Ethanol Extraction Methods of Yanyanfang Buccal Tablets

作　　者：卢进[1] 李瑞明[1] 任斌[1] 陈孝[1] 

机构地区：[1]中山大学附属第一医院,广东广州510080

出　　处：《今日药学》2010年第11期19-22,共4页Pharmacy Today

基　　金：广州市科技攻关重点项目(编号:2007Z2-E5031);广东省中医药局建设中医药强省科研课题重点项目(编号:2007009)

摘　　要：目的探讨并优化咽炎方含片的醇沉方法,为开发咽炎方制剂提供理论依据。方法以乙醇浓度和醇沉时间为影响因素,以土牛膝中总黄酮类提取率和岗梅中总皂苷类提取率为定量指标,设计试验评价最优乙醇体积分数、醇沉时间。结果咽炎方含片的最佳醇沉工艺为乙醇体积分数为80%,醇沉时间24 h。结论优选的醇沉工艺纯化效率高、去除杂质多、质量稳定、重现性好。Objective To explore and optimize the ethanol precipitation methods of Yanyanfang buccal tablets.Methods Different ethanol concentrations and precipitation times were used as influent factors,and total flavone in twotooth achyranthes root and total anemarrhenasaponin in holly root were used as quantitation indexes,in order to explore the best ethanol concentration and precipitation time.Results The best conditions for the ethanol precipitation are： the ethanol concentration 80%,extraction time 24 h.Conclusion This method is convenient,simple,rapid,and is suitable for extraction of Yanyanfang buccal tablets.

关 键 词：土牛膝 岗梅 总黄酮类 总皂苷类 醇沉工艺 

分 类 号：R284[医药卫生—中药学]