防石合剂对实验性大鼠肾草酸钙结石形成的抑制作用  

Inhibition Effect of Anti-stone Composition on Renal Calcium Oxalate Calculus Formation in Experimental Rats

作　　者：赖海标[1] 刘朝晖[1] 吴松[1] 顾向明[1] 王书芹[1] 高玉桥[1] 林慧[1] 汪芸[1] 范文昌[1] 丘兰英[1] 梅全喜[1] 

机构地区：[1]中山市中医院,广东中山528400

出　　处：《今日药学》2010年第11期35-39,共5页Pharmacy Today

基　　金：中山市科技计划资助项目(编号:20071A016);广东省中医药局科技基金资助项目(编号:2007424)

摘　　要：目的研究防石合剂对大鼠肾草酸钙结石形成的抑制作用。方法用1%乙二醇和2%氯化铵诱导大鼠肾草酸钙结石模型,灌胃给予不同剂量的防石合剂,实验结束后进行各组大鼠尿液、血清和肾组织中的多项生化指标[尿素氮(BUN)、肌酐(CR)、尿酸(UA)、无机磷(IP)、钙(Ca2+)]检测以及肾脏病理标本观察。结果和成石模型组比较,防石合剂给药组能降低血清、肾组织和24 h尿中的UA、Ca2+含量,病理切片显示给药组草酸钙结晶明显减少。Objective To investigate the inhibition effect of anti-stone composition on renal calcium oxalate calculus formation in experimental rats.Methods The model of renal calcium oxalate calculus was induced by 1% ethylene glycol and 2% ammonium chloride,and the rats were administered intragastrically with different doses of anti-stone composition.When the experiment was ended,several biochemical indicators[urea nitrogen（BUN）,creatinine（CR）,uric acid（UA）,inorganic phosphorus（IP）,calcium（Ca 2＋）]of urine,blood,and nephridial tissue were measured,and renal pathological specimens were observed.Results The contents of UA and Ca 2＋ of blood serum,nephridial tissue and 24 h urinary in anti-stone composition groups were significantly lower than that in the stone forming group.The renal calcium oxalate calculus of anti-stone composition groups were obviously reduced compared with the stone forming group.Conclusion The anti-stone composition can inhibit renal calcium oxalate calculus formation in experimental rats.

关 键 词：防石合剂 草酸钙 肾结石 大鼠 抑制作用 

分 类 号：R285.5[医药卫生—中药学]