低分子肝素治疗原发性肾病综合征的临床观察  

Clinical observation of Primary nephrotic syndrome treated by low molecular weight heparin

作　　者：杨怡[1] 李小容[1] 罗腾飞[1] 

机构地区：[1]四川省三台县人民医院,四川三台621100

出　　处：《医学信息（中旬刊）》2010年第12期3455-3456,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:探讨使用低分子肝素治疗原发性肾病综合征前后的变化。方法:26例原发肾病综合征患者,采用治疗前后自身对照方法进行研究。口服强的松1mg/(kg.d),4～8周减量;再应用低分子肝素5000U肌注,每日1次,共2周,潘生丁300mg/d,共6周,分别比较治疗前后尿蛋白定量、血清白蛋白、肌酐清除率、尿素氮等指标。结果:低分子肝素可改善高凝状态,降低尿蛋白,升高血清白蛋白,改善肾功能。结论:肾病综合征患者抗凝治疗应作为常规手段,对改善患者症状,预防并发症有重要作用。Objective：To explore the clinical change of Primary nephrotie syndrome patients before and after treatment with low molecular weight heparin （LM- WH）. Methods：The 26 patients with Primary nephrotic syndrome were researched by selfcontrol law before and after treatment. Oral prednisone 1 mg/（ kg. d） ,reduction after 4 -8 weeks; Then, IMLMWH （ 5000U）, 1 time/d, for 2 weeks ; IM Dipyridamole （300mg/d） for 6 weeks, then the Urinary protein, Serum albumin, Creatinine clearance and Urea nitrogen was compared before and after treatment. Results：The LMWH can improve the hypercoagulable state,reduce the urinary protein,increase the serum albumin and improve the renal function. Conclusion ：The anticoagulant therapy should be the conventional means to Primary nephrotic syndrome patients, which plays an important role in improving the symptoms and prevention of comphcations.

关 键 词：低分子肝素(LMWH) 肾病综合征(NS) 

分 类 号：R692[医药卫生—泌尿科学]