我院145例药品不良反应报告分析  

Analysis of 145 ADR reports in our hospital

作　　者：王奎鹏[1] 张贺鸣[2] 韩联合[3] 

机构地区：[1]河南中医学院第一附属医院,河南郑州450000 [2]河南省新乡医学院药学院,河南新乡453003 [3]郑州航空工业管理学院,河南郑州450000

出　　处：《医学信息（中旬刊）》2010年第12期3472-3473,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:了解药品不良反应(ADR)的发生情况,探讨发生ADR的因素,促进临床安全合理用药。方法:对2008年上报的145例ADR报告按患者年龄、性别、给药途径、药品的种类、ADR临床表现等方面进行统计、分析。结果:145例ADR报告中,男69例(占47.57%),女76例(占52.43%);静脉给药是引起ADR的主要给药途径(101例,69.66%);涉及药品104种,其中中药注射剂居多(46种,占44.23%),其次为抗微生物药(31种,占29.81%);临床表现以皮肤及附件损伤最为常见(101例,占40.08%);严重的ADR报告5例(3.45%)。结论:加强ADR监测工作,以避免或减少ADR的发生,确保临床安全合理用药。Objective：To investigate the occurrence of adverse drug reactions （ADRs） and explore the factors that occurred in ADR in our hospital, and promote the safety and rationality of drug use in clinic. Methods ： The 145 ADR reports in our hospital in 2008 year were analyzed statistically in terms of patients＇age distribution, sex, route of administration, drug varieties and the specific clinical manifestations. Result：Of the total 349 ADR cases,69 cases （47.57 % ） were male, and 76 （52. 43% ） were female ;101cases （69.66%） were induced by intravenous routeL;83 the drugs involved 104 kinds,among which traditional Chinese medicine preparations （46 kinds,44.23% ） dominated the first and anti -microbial drugs （31kinds ,29.81% ） dominated the second;skin and the most common clinical manifestations were the damage of skin and its accessories （101 cases,40.08% ） ;severe ADRS were 5 cases （3.45%）. Conclusion：More attention should be paid to the monitoring so as to lessen or avoid the occurrence of ADRs and ensure safety and rationality of drug use in clinic.

关 键 词：药品不良反应 监测 合理用药 

分 类 号：R95[医药卫生—药学]