跨膜蛋白16A:钙激活氯通道的最新进展  

TMEM16A:Advances in Calcium-activated Chloride Channel

作　　者：陈娅斐[1] 李婷[1] 安海龙[1] 于慧[1] 张素花[1] 韩英荣[1] 张玉红[1] 郭鹏[1] 展永[1] 

机构地区：[1]河北工业大学理学院生物物理研究所,天津300401

出　　处：《生物化学与生物物理进展》2010年第11期1175-1181,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(10975045;10775038);河北省自然科学基金(C2009000029)资助项目~~

摘　　要：钙激活氯离子通道(calcium-activated chloride channels,CaCCs)介导了众多生理过程,包括跨上皮离子与液体分泌、心肌和神经兴奋、感觉传导、平滑肌收缩和受精过程等,但目前对于其分子基础等重要问题尚未研究清楚.综述了最新报道的CaCCs分子基础跨膜蛋白16A(TMEM16A)的发现过程、基因结构和功能、离子通道电生理特性、相关病理与药理功能的一些热点问题,并展望了该研究领域的发展趋势.Calcium（Ca^2＋） -activated chloride channels play fundamental roles in numerous physiological processes including transepithelial ion/fluid secretion,cardiac and neuronal excitation,sensory transduction,smooth muscle contraction and fertilization,etc.Despite their physiological importance,the molecular identity of CaCC has not fully invested till now.Here the newly discovered CaCCs molecular basis TMEM16A was reviewed in the respects of the identification processes,gene structure and functions,ion channel’s electrophysiological characters,related diseases,pharmocoligical functions and other current hot issues in the fields.The developmental trends of this field were discussed.

关 键 词：钙激活氯离子通道 分子基础 跨膜蛋白质16A 电生理 药理学 

分 类 号：Q63[生物学—生物物理学] R96[医药卫生—药理学]