苄星青霉素治疗早期显性梅毒的疗效分析  

Efficiency of Benzathine Benzylpenicillin on Early Symptomatic Syphilis

作　　者：刘赵明 

机构地区：[1]德阳市医院皮肤科,四川德阳618000

出　　处：《华西医学》2010年第10期1849-1851,共3页West China Medical Journal

摘　　要：目的观察使用苄星青霉素正规治疗早期显性梅毒的临床疗效以及分析治疗前后的梅毒血清学试验结果。方法选择2006年6月-2007年12月门诊就诊有皮肤损害的早期梅毒患者48例,病程<2年,采用苄星青霉素240万U,肌内注射,1次/周,连续3周治疗。治疗后随访第3、6、9、12、18、24个月时的TRUST滴度。结果 48例早期梅毒患者经治疗后1个月内皮损均消失。总的血清转阴率为66.67%。一期梅毒在治疗后3、6个月时的TRUST转阴率较二期梅毒高(P<0.05)。治疗前TRUST≥1:8者TRUST滴度在治疗后下降较TRUST≤1:4者快(P<0.05)。结论早期梅毒病程越短,治愈越快。治疗前血清学滴度越高,治疗后滴度下降越快。梅毒的治疗应强调早期、规范。Objective To analyze the clinical efficiency and pre-and post-therapy serological results of benzathine benzylpenicillin treated for early symptomatic syphilis.Methods A total of 48patients with early symptomatic syphilis diagnosed from June 2006to December 2007（the disease duration〈2years）were treated with benzathine benzylpenicillin.The patients underwent the intramuscular injection with 2.4million units benzathine benzylpenicillin once per week（for continuous 3weeks）.The results of TRUST were detected 3,6,9,12,18,and 24 months after the treatment.Results All patients cured clinically within one month.The general seronegative rate was 66.67%.Three and six months after the treatment,the seronegative rate of primary syphilis were higher than that of secondary syphilis（P〈0.05）.The TRUST titer dropped faster after the treatment in the ones whose TRUST titer was≥1：8than those whose TRUST titer was≤1：4（P〈0.05）.Conclusion The shorter the duration of infection is,the faster the treatment may be.The higher the TRUST titers before the treatment are,the faster the titers decrease is.The treatment on syphilis should be as early as possible.

关 键 词：梅毒 血清学 苄星青霉素 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]