慢性心力衰竭住院患者的合并症对药物治疗影响的研究  

The Effect of Patient Complications on Drug Treatment of Chronic Heart Failure

作　　者：郭慧卿[1] 王林[1] 黄娇红[1] 马金萍[1] 

机构地区：[1]天津医科大学第二医院心脏科,300211

出　　处：《天津医药》2010年第11期944-947,共4页Tianjin Medical Journal

基　　金：天津市科委重点基金资助项目(项目编号:033111311)

摘　　要：目的:了解慢性心力衰竭患者的并发症是否对血管紧张素转换酶抑制剂(ACEI)、β-受体阻滞剂、血管紧张素Ⅱ受体拮抗剂(ARB)等药物的治疗产生影响。方法:选取1973年7月—2007年7月间的慢性心力衰竭住院患者,进行回顾性调查,包括年龄、性别、病因、合并症、电解质、心功能以及ACEI、β-受体阻滞剂、ARB等药物的应用情况。根据年代分为A(1973～)、B(1980～)、C(1990～)、D(2000～2007)共4组。结果:入选6602例次,男3325例次(50.4%),女3277例次(49.6%)。合并高血压、糖尿病、脑血管病、肾功能不全、贫血在4组中差异有统计学意义。ACEI、ARB和β-受体阻滞剂在合并高血压、糖尿病、慢性肾功能不全、贫血等患者中的应用比例均高于无合并症者,并于最近年代中的应用比例增加。结论:在某种程度上,高血压、糖尿病、脑血管病、慢性肾功能不全、贫血等合并症的存在使慢性心力衰竭患者使用ACEI、ARB和β-受体阻滞剂机会增加。Objective： To investigate the relationship of the complications in hospitalized chronic heart failure patients and the drug therapy of angiotensin converting enzyme inhibitors （ACEI）, β-receptor blockers and angiotensin receptor antagonists（ARB）. Methods： All patients with chronic heart failure, hospitalized between July 1973 and July 2007 in the second hospital of Tianjin Medical University, were collected from medical record library. The retrospective index included age, gender, etiology, complications, risk factors, electrolytes, heart function and drug therapy of ACEI, β-receptor blockers and ARB. All data were collected by SPSS 13.0. And all data were divided with a decade interval into group A （1973-）, group B （1980-）, group C （1990-） and group D （2000-2007）. Results： There were 6 602 patients in this study including 3 325 male （50.4%） and 3 277 female （49.6%）. There were significant differences in patients combined with hypertension, diabetes mellitus, cerebrovascular disease, renal inadequacy and anemia between the groups. There were higher application ratios of ACEI, β-receptor blockers and ARB in patients combined with hypertension, diabetes mellitus, renal inadequacy and anemia than those of control. And in recent years, the application of these drugs increased gradually. Conclusion： To some extent, chronic heart failure patients combined with hypertension, diabetes mellitus, cerebrovascular disease, chronic renal insufficiency and anemia were more likely to use ACEI, β-receptor blockers and ARB.

关 键 词：心力衰竭 血管紧张素转换酶抑制药 血管紧张素Ⅱ 1型受体拮抗剂 肾上腺素能Β受体拮抗剂 治疗回顾性研究 

分 类 号：R541.61[医药卫生—心血管疾病]