心衰模型大鼠脉搏波变化的分析  

Research of pulse wave’s features about rats of CHF model

作　　者：汪南玥[1] 于友华[1] 黄大威 闪增郁[1] 陈燕萍[1] 李同达[1] 

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]中国基础科学研究院贝尔实验室,北京100080

出　　处：《中华中医药杂志》2010年第12期1953-1955,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十一五"科技支撑计划项目(No.2006BAI08B01-02);基本科研业务费课题(No.ZZ2006043)~~

摘　　要：目的:研究心衰模型大鼠脉搏波的变化及其规律。方法:在麻醉状态下,采集主动脉缩窄术心衰模型大鼠双侧股动脉脉搏波,并与假手术组进行对照。选取连续的多个周期的脉搏波做为研究对象,对各个周期进行6次谐波的最小二乘回归并建立数学模型并获取33个特征参数,根据上述参数对心衰大鼠的脉搏波进行特征分析和分类,寻找出该模型大鼠脉搏波的特征参数。结果:手术前、后与模型后等不同状态时大鼠脉搏波都出现了规律性的变化,腹主动脉的缩窄手术在大鼠脉搏波上主要表现为右侧第5谐波的相位改变,而长期缩窄后对心血管系统的影响而出现了第2谐波能量的变化。结论:心衰模型大鼠股动脉脉搏波上出现了特征性改变,提示体表的动脉脉搏波可以反映机体内脏的变化,为中医脉诊方法提供了一定的科学依据和研究参考。Objective： To study the features of rats＇ pulse waves of CHF Model. Methods： To collect the pulse waves of femoral artery in each side of rats in Drugged state. Then do constriction of abdominal aorta operation and collect the pulse waves again, and collect them the 3rd time after 70 days. To analyze continuous cycles waves with different period length and then do the LSQ regression by 6 halmonics fitting which are correspond with every cycle lengths, do the statistic research by the 33 characters we extracted and do classification and identification to find out the features of the models. Result： There＇re some regular changes between the pulse waves of rats before operation and rats after operation and also between CHF model rats by constriction of abdominal aorta and the rats by sham operation, F5R is the feature of the operation and the C2 and F5R are the features of CHF model rats by constriction of abdominal aorta. Conclusion： We have found some features in the pulse waves of CHF model rats which show that the pulse waves of artery on the body surface can reflect the visceralis changes. This research can offer some scientific foundation to the pulse-diagnosis in TCM.

关 键 词：心衰模型大鼠 脉搏波 分类识别 特征参数 谐波拟合 

分 类 号：R541.6[医药卫生—心血管疾病]