固本防哮饮联合穴位敷贴治疗儿童哮喘缓解期100例临床研究  

Clinical research of Gubenfangxiao decoction combined with point application on chronic asthmatic children in 100 cases

作　　者：袁雪晶[1,2] 孙轶秋[1] 王素梅[3] 李燕宁[4] 王孟清[5] 刘晓冉[2] 汪受传[2] 

机构地区：[1]南京中医药大学附属医院,南京210029 [2]南京中医药大学第一临床医学院,南京210029 [3]北京中医药大学附属东方医院,北京100078 [4]山东中医药大学附属医院,济南250011 [5]湖南中医药大学第一附属医院,长沙410007

出　　处：《中华中医药杂志》2010年第12期2306-2309,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十一五"科技支撑项目(No.2007BAI20B021)~~

摘　　要：目的:初步评价固本防哮饮联合穴位敷贴治疗儿童哮喘缓解期肺脾气虚证的有效性和安全性。方法:采用中心随机、平行对照的试验原则,对100例哮喘缓解期患儿进行临床研究,试验组51例,对照组49例,试验组采用固本防哮饮口服配合中药穴位敷贴;对照组用普米克都保(布地奈德)吸入,疗程均为6个月。结果:①单指标疗效评价:治疗前后疗效比较,试验组患儿哮喘发作次数显著减少,上、下呼吸道感染次数减少,与基线比较,有极显著性差异(P<0.01);试验组和对照组疗效比较,在维持哮喘患儿无喘息症状的天数,控制哮喘发作次数方面,与普米克都保疗效相近,但能更显著地减轻哮喘发作的严重度,6个月时试验组Ⅱ级以上的哮喘发作明显低于对照组,有极显著性差异(P<0.01)。试验组6个月时上呼吸道感染次数显著少于对照组,有显著性差异(P<0.05),提示试验组能更好地预防呼吸道感染的发生。②总疗效评价:试验组总有效率86.27%,控显率60.78%;对照组总有效率73.46%,控显率44.89%,两组比较有显著性意义(P<0.05)。结论:固本防哮饮联合穴位敷贴治疗儿童哮喘缓解期肺脾气虚证安全有效。Objective：To evaluate the efficacy and safety of Gubenfangxiao decoction（GBFXD）combined with point application on chronic asthmatic children with asthenia of deficiency of lung ang spleen qi.Methods：A central randomized,parallel controlled method was used to carry out clinical studies on 100 cases of chronic asthmatic children.there are 51 cases in observation group and 49 cases in control group.Children were orally administered GBFXD combined with point application in observation group and inhaled Pulmicort Turbuhaler in control group,the treating period was 6 months.Results：①Mono-target evaluation：Compared to baseline,the times of asthma attack,upper and lower respiratory infection were significantly reduced after treatment,meanwhile,the non-gasping days and the times of asthma attack were similar in two groups.But the severity of asthma attack in observation group was more effectively alleviated,and the times of asthma attack above 2 class was significant lower than control group.The times of upper respiratory infection in observation group were obviously lower than control group,indicated that the GBFX combined with point application treatment might prevent respiratory infections.②Total therapeutic effect evaluation：The total effective rate was 86.27% in observation group,73.46% in control group and the controlled and remarkable effective rate was 60.78%in observation group and 44.89%in control group,respectively.Conclusion：The treatment of oral administration GBFXD combined with point application on chronic asthmatic children with asthenia of deficiency of lung ang spleen qi was effective and safety.

关 键 词：支气管哮喘 儿童 肺脾气虚证 中医药疗法 临床研究 

分 类 号：R272[医药卫生—中医儿科学]