肠安Ⅰ号对实验性腹泻型肠易激综合征大鼠结肠黏膜NF-κB的影响  

Influence of NF-κB of rat colon by Chang’an I for experimental D-IBS

作　　者：林媚[1] 唐旭东[2] 王凤云[2] 

机构地区：[1]北京中医药大学第一临床医学院,北京100029 [2]中国中医科学院西苑医院,北京100091

出　　处：《中华中医药杂志》2010年第12期2339-2341,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：科技部国际科技合作项目(No. 2007DFA30560)~~

摘　　要：目的:通过观察肠安I号对大鼠结肠黏膜NF-κB影响,探讨促炎因子NF-κB的活化在IBS发病机制中的作用。方法:用免疫组化方法检测大鼠结肠黏膜NF-κB含量。结果:肠安I号各剂量组IOD降低与模型组比较有统计学意义(P<0.05)。结论:肠安I号各剂量组对D-IBS作用机制可能与抑制NF-κB的活化有关。Objective：To explore NF-κB activation in the role of pathogenesis of IBS by observation of NF-κB of rat colon of Chang’an.Method：Detected content of NF-κB of rat colon by IHC.Result：There were statistic difference of IOD of each group of Chang’an I compared with model group（P0.05）.Conclusion：The mechanism of action of each group of Chang’an I had relation with inhibition of the activation of NF-κB.

关 键 词：肠易激综合征 中药治疗 

分 类 号：R285.5[医药卫生—中药学]