血小板活化因子CD62P和CD63的表达在急性脑梗死中的临床意义  

Clinical Significance of Platelet CD62P and CD63 Expression in Patients with Acute Cevebral Infarction

作　　者：徐培敬[1] 张枫林[1] 陈颖[1] 韩雪花[2] 

机构地区：[1]徐州医学院附属淮安市二医院老年科,江苏省淮安市223002 [2]徐州医学院附属淮安市二医院中心实验室,江苏省淮安市223002

出　　处：《中国动脉硬化杂志》2010年第9期744-745,共2页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨血小板α颗粒膜糖蛋白CD62P和溶酶体膜糖蛋白CD63的表达与急性脑梗死的关系。方法用流式细胞仪和单克隆抗体标记法检测61例急性脑梗死患者CD62P和CD63水平,并与59例正常对照组比较。结果急性脑梗死患者CD62P和CD63的表达明显高于正常对照组(6.26%±1.68%比2.32%±1.14%和6.14%±1.89%比2.88%±1.15%,P<0.01)。结论急性脑梗死患者血栓的形成与血小板的活化密切相关,且活化血小板的检测可以作为脑梗死早期诊断一项较特异的指标。Aim To investigate the relationship between platelet CD62P and CD63 expression and acute cevebral infarction（ACI）. Methods The expression of CD62P,CD63 was detected by flow cytometry in 61 patients with acute cevebral infarction（ACI）,and 59 healthy control subjects. Results CD62P,CD63 in acute cevebral infarition were 6.26%±1.68% vs 2.32%±1.14%,6.14%±1.89% vs 2.88%±1.15% respectively,and the result has statistical significance compa with those of the control group（P〈0.01）. Conclusion The formation of thrombus in actute cerebral infaration patients is highly related to the platelets activation,which can be a diagnostic indicator of cevebral infarction disease.

关 键 词：急性脑梗死 活化血小板 流式细胞术 

分 类 号：R5[医药卫生—内科学]