隔药饼灸对不同年龄健康人红细胞CD58表达的影响  

Effects of herbal cake-separated moxibustion on the expression of erythrocyte CD58 in different ages of healthy people

作　　者：田岳凤[1] 李雷勇[2] 王军[1] 张斌仁[1] 王格洪[1] 解博翔[1] 袁叶[1] 

机构地区：[1]山西中医学院针灸推拿系,太原030024 [2]山西医科大学第二医院

出　　处：《中国针灸》2010年第11期933-935,共3页Chinese Acupuncture & Moxibustion

基　　金：山西省科技厅攻关项目:20080312015

摘　　要：目的:观察灸法对不同年龄健康人群红细胞表面白细胞分化抗原58(CD58)表达的影响,探讨其对不同年龄人群的效应差异及艾灸预防疾病的作用机制。方法:82例健康人按年龄分为青年组和中老年组。将以熟地、山药、山茱萸等为主方的药物制成药饼置于神阙、关元、足三里、脾俞、肾俞施隔药灸,每穴3壮,隔日1次,共灸10次。分别于施灸前、施灸10次(1疗程)后各抽取静脉血2mL,用流式细胞仪测定红细胞表面CD58分子的平均荧光强度。结果:隔药饼灸后,青年组与中老年组红细胞CD58分子的荧光强度均明显高于施灸前(均P<0.01),红细胞CD58均呈高表达状态。其中,青年组的变化尤为突出,其增高幅度与中老年组比较差异有统计学意义(P<0.01)。结论:艾灸对青年人的效应优于中老年人,其预防疾病的作用机制为增强了红细胞CD58的高表达。Objective To observe the efficacy of herbal cake-separated moxibustion on the expression of erythrocyte CD58 in different ages of healthy people and explore the differences of the therapeutic effect in different ages and its mechanism. Methods A total of 82 health participants were divided into a young age group and a middle-old age group according to the ages. They were treated with herbal cake-separated moxibustion on Shenque （CV 8）, Guanyuan （CV 4）, Zusanli （ST 36）, Pishu （BL 20）, Shenshu （BL 23） with cake made by Shudihuang （Radix Rehmanniae Preparata ）, Shanyao （Rhizoma Dioscoreae ） , Shanzhuyu （ Fructus Corni ） , etc. The treatment was given for 10 sessions once other day and each acupoint for 3 successive dosages. The mean fluorescence intensities of erythrocyte CD58 were measured by flow cytometry before and after moxibustion. Results After moxibustion, erythrocyte CD58 expression were significantly higher than that before moxibustion in two groups （both P〈0. 01）, particularly in young age group, which was significantly higher than that in middle-old age group （P〈0.01）. Conclusion The effect of moxibustion in youth is evidently superior to that in middle-old age. Its mechanism is connected with that moxibustion can enhance the expression of erythrocyte CD58.

关 键 词：艾灸疗法 红细胞CD58 基因表达 红细胞免疫 

分 类 号：R245.8[医药卫生—针灸推拿学]