青春前期儿童甲状腺功能减退致垂体增生及文献复习  

作　　者：王良伟[1] 刘策刚[1] 陶进[1] 邵雪非[1] 

机构地区：[1]安徽省芜湖市皖南医学院弋矶山医院神经外科,安徽芜湖241001

出　　处：《国际神经病学神经外科学杂志》2010年第5期397-399,共3页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨青春前期儿童甲状腺功能减退症的诊断及治疗原则。方法回顾一例青春前期儿童甲状腺功能减退致垂体增生的临床资料。结果患者表现为促甲状腺素(TSH)、泌乳素(PRL)升高,FT3和FT4减少,MRI示垂体增大,甲状腺素替代治疗6个月后,垂体基本恢复正常大小,TSH、PRL、T3、T4基本恢复正常。结论青春前期儿童甲状腺功能减退症通过临床表现、影像学的特征表现以及实验室检查可以明确诊断。甲状腺素的替代治疗为首选而不宜手术治疗。Objective To discuss the diagnosis and management of pituitary hyperplasia secondary to hypothyroidism in preadolescent children.Methods The clinical data of one child with pituitary hyperplasia secondary to primary hypothyroidism at preadolescence were studied retrospectively and literatures were reviewed.Results The thyroid hormone levels decreased and the serum thyroid stimulating hormone （TSH） and prolactin （PRL） levels increased.Magnetic resonance imaging revealed pituitary hyperplasia.Both symptoms and pituitary hyperplasia regressed to normal after six months of adequate hormone replacement therapy with thyroxin.The levels of triiodothyronine （T3）,thyroxine （T4） and serum TSH and PRL returned to normal.Conclusions Pituitary hyperplasia secondary to hypothyroidism has some endocrine changes and MRI characteristics.Thyroxin substitution therapy should be the first line treatment but not surgery.

关 键 词：甲状腺功能减退 垂体增生 青春前期儿童 

分 类 号：R725.8[医药卫生—儿科]