脂联素基因单核甘酸多态性与汉族人群肥胖易感性的关系  

Relationship of adiponectin gene polymorphism and susceptibility to obesity in Han population

作　　者：解正林[1] 杜文聪[2] 陆莹[2] 高燕勤[1] 俞晓芳[1] 杜娟[2] 石慧[2] 叶青[2] 赵旭[2] 曹园园[2] 周玲[2] 

机构地区：[1]南京医科大学第三附属医院内分泌病科,仪征市211900 [2]南京医科大学公共卫生学院流行病与卫生统计学系

出　　处：《江苏医药》2010年第21期2485-2487,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金项目(30771858);江苏省自然科学基金项目(BK2007229)

摘　　要：目的探讨脂联素基因两个单核甘酸位点多态性与汉族人群肥胖易感性的关系。方法选取肥胖组483例,对照组517例为研究对象,用RT-PCR联合TaqMan-MGB探针检测基因型。结果携带脂联素基因rs2241767AG和AG/GG基因型者较AA基因型者发生肥胖的风险增加,尤其在男性、<50岁、高血脂或不吸烟/戒烟群体中,AG/GG基因型者发生肥胖的风险增加。女性携带该基因rs12495941位点GT/TT型较GG型者发生肥胖的风险增加。结论脂联素基因两位点(rs2241767、rs12495941)多态性改变可能与汉族人群肥胖有关。Objective To explore the relationship of adiponectin gene polymorphism and susceptibility to obesity in Han population.Methods RT-PCR and Taqman-MGB probe were performed to test the genotypes in 483 obesity cases（group A）and 517 normal controls（group B）.Results The variant genotypes,rs2241767 AG or AG/GG had a higher risk for obesity than AA gene,especially in those of male,50 years old,lipoemia and nonsmoking.The females carrying rs12495941 GG/GT genotypes had a higher risk for obesity than those with GG genotype.ConclusionThe rs2241767 and rs12495941 polymorphism of adiponectin gene may play a role in the susceptibility of obesity in Han population.

关 键 词：脂联素基因 肥胖 单核甘酸多态性 

分 类 号：R589[医药卫生—内分泌]