阻塞性睡眠呼吸暂停低通气综合征患者血清脑红蛋白测定及其与病情的相关性  

Detection of serum NGB in OSAHS patients and its relationship with the severity of OSAHS

作　　者：刘亚辉[1] 叶辉[1] 高凯[1] 康宁[1] 詹斌[1] 

机构地区：[1]厦门市第二医院耳鼻咽喉科,福建厦门361021

出　　处：《中国耳鼻咽喉颅底外科杂志》2010年第5期359-361,共3页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清脑红蛋白(NGB)的含量,探讨脑缺氧程度与OSAHS患者的相关性,为临床进行脑保护提供理论依据。方法选取OSAHS患者48例及非OSAHS病例45例作为对照,均经多导睡眠监测(polysomnography,PSG)及血清脑红蛋白检测。所有入选者在睡眠监测结束后晨醒3min内采取肘静脉血,检测血清NGB。结果 OSAHS组与对照组比较血清NGB浓度升高,两组比较有统计学意义(P<0.05)。直线相关分析显示OSAHS患者血清NGB水平与最低血氧饱和度(LSaO2)呈负相关(r=-0.768),血清NGB水平与睡眠呼吸监测指标AHI呈正相关(r=0.788)。结论 OSAHS患者睡眠中病情越重脑缺氧越严重。Objective To study the relationship between the hypoxia injury of brain and obstructive sleep apnea- hypopnea syndrome （ OSAHS ） by means of detection of neuroglobin （ NGB ） and to provide theoretical foundation for clinical neuroproteetion. Methods 48 patients were diagnosed having OSAHS with polysoinnography （PSG） and 45 normal health adults were selected as control. Serum NGB concentration in both OSAHS and control groups was measured. Results The serum NGB level of OSAHS patients was higher than that of normal control with significant difference （ P 〈 0. 05 ） . The linear correlation analysis showed that the serum NGB level was positively correlated with AHI （ r = 0. 788 ） , but negatively with LSaO2 （ r = -0.768 ） in OSAHS. Conclusion During sleep period of OSAHS, hypoxia injury of brain may occur, which is positively correlated with the severity of OSAHS.

关 键 词：睡眠呼吸暂停低通气综合征 脑红蛋白 多导睡眠监测 

分 类 号：R766.4[医药卫生—耳鼻咽喉科]