血清高敏C反应蛋白与血压的关系  

Relationship between high-sensitive c-reactive and blood pressure

作　　者：张海锋[1] 朱桢燕[1] 姚文明[1] 徐芳[1] 梁宁霞[1] 龚磊[2] 赵国祥[2] 姚学仁[2] 殷志建 吴志军 陈福宽[4] 孙大勤[4] 李新立[1] 曹克将[1] 

机构地区：[1]南京医科大学第一附属医院心内科,210029 [2]高邮市卫生局 [3]江苏省高邮市八桥中心卫生院 [4]江苏省高邮市送桥中心卫生院

出　　处：《中华心血管病杂志》2010年第11期993-997,共5页Chinese Journal of Cardiology

基　　金：“十一’五”国家科技支撑计划“慢性阻塞性肺炎等疾病防治技术研究”（2007BA107A10）;“十一·五”国家科技支撑计划“全科型乡镇卫生院技术集成综合示范”（2008BA165B09）

摘　　要：目的 探讨自然人群中C反应蛋白与血压的关系.方法 在江苏省高邮市八桥镇随机人选了3889名18～74岁农村居民,使用标准流行病学调查表进行问卷,并测量血压,空腹抽血常规生化检查,免疫比浊法测量高敏C反应蛋白（hCRP）.按hCBP四分位间距将男性与女性分别分为4组：Q1组（男性hCRP＜2.04 mg/L;女性hCRP＜1.80 mg/L）;Q2组（男性2.04 mg/L≤hCRP＜3.01mg/L;女性1. 80 mg/L≤hCRP＜2.76 mg/L）;Q3组（男性3.01 mg/L≤hCRP＜4.14 mg/L;女性2.76mg/L≤hCRP＜3.84 mg/L）;Q4组（男性hCRP≥4.14 mg/L;女性hCRP≥3.84 mg/L）.结果 男性的收缩压（调整后P=0.016）与脉压（调整后P=0.003）、女性脉压（调整后P=0.002）随CRP浓度增高而增高,而舒张压与CRP无显著相关.多元回归提示logCRP增高与男性收缩压及男女脉压升高独立相关.调整年龄、体质指数、腰臀比、吸烟史、饮酒史等变量,hCRP与男性高血压发病独立相关,男性Q4组高血压患病风险较Q1组增高40.4%（95%可信区间：4.9%～87.9%）.结论 hCRP增高与男性与女性脉压增高,及男性收缩压增高与高血压发病的独立相关.Objective To investigate the relationship between c-reactive protein （CRP） and blood pressure in a general population. Methods We randomly selected 3889 subjects aged 18 -74 years stratified by gender and age in Baqiao, a rural area of Jiangsu Province. A standardized questionnaire was used to collect information on medical history, smoking, alcohol intake and use of medications. Blood pressure was measured by mercury sphygmomanometer. Serum CRP （hCRP） concentration was measured using a high sensitivity BNprosec immunonephelometric assay. Subjects were divided into 4 groups according to their interquartile range of CRP levers： group Q1 （ men hCRP 〈2. 04 mg/L;women hCRP 〈 1.80 mg/L）;group Q2 （ men 2. 04 mg/L ≤ hCRP 〈 3.01 mg/L; women 1.80 mg/L ≤ hCRP 〈 2. 76 mg/L）; group Q3（men 3.01 mg/L≤ hCRP 〈4. 14 mg/L;women 2.76 mg/L ≤ hCRP 〈3. 84 mg/L）;and group Q4（men 4. 14 mg/L≤hCRP;women 3. 84 mg/L ≤ hCRP）. Results Systolic blood pressure （ SBP, adjusted P =0. 016 ） and pulse pressure （ PP, adjusted P =0. 003 ） of men and PP （ adjusted P =0. 002） of women were increased in proportion to increased CRP levels. Diastolic blood pressure was not associated with CRP levels. Multiple stepwise regression analysis showed that logCRP was independently associated with SBP and PP in men and PP in women. hCRP was independently associated with hypertension in men. Compared with group Q1, male people in group Q4 faced a40. 4% （95% confidence interval：4. 9% -87.9% ） higher risk of hypertension. Conclusions hCRP was independently associated with PP in men and women, and SBP in men. hCRP was independently associated with hypertension in men but not in women in this study population.

关 键 词：高血压 C反应蛋白 

分 类 号：R686[医药卫生—骨科学]