实时动态血糖监测与静脉血糖、毛细血管血糖检测的相关性  

Correlation of real-time continuous monitoring system with venous glucose and capillary glucose values

作　　者：李强[1] 王莹莹[1] 于萍[1] 高萍[1] 邬艳慧[1] 崔璨[1] 王薇[1] 陈莉丽[1] 乔虹[1] 王丽宏[1] 项莹[1] 张众[1] 张巾超[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科,150086

出　　处：《中华医学杂志》2010年第42期2971-2975,共5页National Medical Journal of China

基　　金：基金项目：美国亚洲糖尿病研究基金会科研项目（2009-08.12）;哈尔滨市科技攻关项目（2007AA3CS084）;上海市新兴前沿技术联合攻关项目（SHDCl2006101）

摘　　要：目的 研究实时动态血糖监测系统（RT-CGMS）与静脉血糖、毛细血管血糖检测的相关性.方法 收集2009年8至12月在哈尔滨医科大学附属第二医院治疗的33例糖尿病患者佩戴5 dRT-CGMS,期间测定静脉和毛细血管血糖值.应用相关分析、Clarke误差表格分析、Bland-Altman分析比较RT-CGMS与静脉血糖及毛细血管血糖的相关性 计算患者佩戴RT-CGMS期间的平均血糖波动幅度（MAGE）.结果 （1）RT-CGMS与静脉、毛细血管血糖值的相关系数分别为0.936和0.933（均P〈0.01）.（2）Clarke误差表格分析显示静脉组和毛细血管组分别有98.67%和98.64%的点位于A区（临床准确区）与B区（临床可接受区） 没有点位于C区（数据误差区） 分别有1.33%和1.36%的点位于D区（数据错误区）.（3）Bland-Altman分析RT-CGMS与静脉血糖、毛细血管血糖值在（x）±1.96范围内.（4）MAGE相同的患者HbA1c差异较大.结论 RT-CCMS与静脉血糖、毛细血管血糖检测具有良好的相关性、准确性和一致性.Objective To study the correlation of real-time continuous monitoring system （RT-CGMS） with venous glucose and capillary glucose values. Methods A total of 33 diabetics received RT-CGMS for 5 days. Fasting venous glucose values were measured at Days 1, 3 and 5 and capillary glucose values recorded 7 times daily. The methods of correlation coefficient, error grid analysis（EGA） and BlandAltman analysis were employed to assessed the correlation, accuracy and agreement of RT-CGMS with venous glucose and capillary glucose values respectively. The mean amplitude of glucose excursions （MAGE） was calculated during RT-CGMS testing periods. Results （1） The correlation coefficient of RT-CGMS with vein glucose and capillary glucose values were 0. 936, 0. 933 （P 〈 0. 01） （2） The analysis results of EGA showed that 98. 67%, 98. 64% of venous and capillary values fell in the A and B zones and 1. 33%,1.36% fell in the D zone （3） The agreement analysis showed that RT-CGMS readings were in close agreement with venous glucose and capillary glucose results （4） The patients at the same M AGE levels had obvious differences in HbAlC. Conclusion There is a high level of correlation, accuracy and agreement between RT-CGMS and venous glucose and capillary glucose values.

关 键 词：糖尿病 血糖自我监测 血糖波动 

分 类 号：R686[医药卫生—骨科学]