几种纳米材料细胞毒性效应的研究现状  

Study on cytotoxic effects of several types of nano-materials:the current status

作　　者：张艳芳[1,2] 金婵[2] 马春旺[1] 杨勇骥[2] 

机构地区：[1]河南师范大学物理与信息工程学院理论物理研究所,新乡453007 [2]第二军医大学基础部生物物理教研室,上海200433

出　　处：《第二军医大学学报》2010年第11期1234-1238,共5页Academic Journal of Second Military Medical University

基　　金：国家重点基础研究发展计划(2006CB932505);上海市科学技术委员会纳米专项(0752nm020)~~

摘　　要：随着社会经济、科技的发展,纳米材料在各个领域中的应用也越来越广泛,在给人们生活带来便利的同时,纳米材料的毒性效应也日益受到人们的高度关注。本文就纳米材料的特殊物理化学特性、纳米材料细胞生物毒性的研究方法、纳米材料对细胞造成的毒性效应等方面,综合阐述几种纳米材料(碳基纳米材料、金属及金属氧化物等)的细胞毒性效应及存在的问题。最后,展望了该研究方向的研究重点和亟待研究的重要问题,为研究纳米材料的生物安全性提供导向。Nano-materials have been increasingly widely used in various fields with the progression in science and technology. While bringing benefit to our life, their toxic effects also come to our attention. In this paper we review the cytotoxic effects and some problems of several kinds of nano-materials （carbon-based nano materials, metal and metallic oxides and other nano-materials）, considering the physicochemical characteristics of nano materials, research methods of the nanomaterial cytotoxie effects, and the cytotoxcity of nano-materials. Finally, we also discuss the research focus of the area and issues need to be addressed, hoping to provide a guide for bio safety research of nano-materials.

关 键 词：纳米材料 细胞毒性效应 生物安全性 

分 类 号：R12[医药卫生—环境卫生学]