C反应蛋白和肺功能测定在哮喘患者中的临床意义  

Clinical significances of C reactive protein and lung function detecting in patients with asthma

作　　者：陈碧华[1] 佘步君 王丹[1] 杨璎 

机构地区：[1]上海市徐汇区枫林街道社区卫生服务中心,上海200030

出　　处：《现代中西医结合杂志》2010年第35期4517-4518,4521,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的研究哮喘患者不同时期血清C反应蛋白(CRP)和肺功能测定的临床意义。方法 85例哮喘患者(哮喘组)和23例健康对照者(对照组)为研究对象,测定哮喘组急性发作期、慢性持续期、缓解期及对照组的血清CRP、血常规、肺功能及动脉血气。结果哮喘组急性发作期血清CRP、外周血白细胞计数(WBC)及动脉血二氧化碳分压(p(CO2))均明显高于慢性持续期、缓解期和对照组(P均<0.01);哮喘组急性发作期FEV1%、FEV1/FVC%及动脉血氧分压(p(O2))均明显低于慢性持续期、缓解期和对照组(P均<0.01);哮喘组慢性持续期、缓解期CRP水平均高于对照组(P均<0.05)。病情3,4级哮喘患者慢性持续期FEV1%、FEV1/FVC%较第1,2级明显下降(P<0.05或0.01)。结论血清CRP可作为判断哮喘患者病情的一个炎性反应指标,有助于哮喘的诊断与疗效观察。Objective It is to study the clinical significances of serum C reactive protein（CRP） and lung function detecting in patients with asthma in different periods.Methods 85 patients with asthma（asthma group） and 23 healthy persons（control group） were study objects.The serum CRP,blood routine examination,pulmonary function and arterial blood gas in asthma group in acute episode period,chronic persistent period and paracmasia and in control group were detected.Results The serum CRP level,lencocyte counts and arterial partial pressure of carbon dioxide（p（CO2）） in asthma group in acute episode period was obviously higher than that in chronic persistent period,paracmasia and control group（all P0.01）.FEV1%,FEV1/FVC% and arterial partial pressure of oxygen（p（O2）） in asthma group in acute episode period was obviously lower than that in chronic persistent period,paracmasia and control group（all P0.01）.The serum CRP level in asthma group in chronic persistent period and paracmasia were both higher than that in control group（both P0.05）.FEV1% and FEV1/FVC% in chronic persistent period patients with asthma in level 3 or 4 were obviously decreased than that in level 1 or 2（P0.05 or 0.01）.Conclusion Serum CRP level can be as a biomarker of inflammation to judge the severity of illness in patients with asthma.It is helpful to diagnose and observe therapeutic efficacy of asthma.

关 键 词：支气管哮喘 C反应蛋白 肺功能 动脉血气 

分 类 号：R541.4[医药卫生—心血管疾病]