Toll受体-myd88通路与异氟烷预处理脑保护的研究新进展  

Interference of toll like receptor-mediated Myeloid Differentiation factor 88-Dependent signaling pathway on isoflurance preconditioning induced cerebral protection

作　　者：肖志彬[1] 吕苗苗[1] 孙绪德[1] 

机构地区：[1]第四军医大学唐都医院麻醉科,陕西西安710038

出　　处：《现代生物医学进展》2010年第21期4192-4194,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30972833)

摘　　要：研究表明,吸入麻醉药可作用于KATP通道、拮抗兴奋性氨基酸及抑制氧自由基生成等,从而诱导脑缺血耐受。但是,上述结果并未揭示与吸入麻醉药预处理脑保护效应相关的细胞内信号机制,目前,对Toll样受体(TLRs)家族的广泛研究揭示部分TLRs受体与全身重要器官的缺血再灌注损伤有关,本文就以异氟烷为代表的吸入麻醉药预处理与脑保护的研究进展及参与脑缺血再灌注损伤的TLRs受体信号通路综述如下。Studies have demonstrated that volatile anestheties may provide protection against cerebral ischemia/reperfusion in-jury through the folllowing mechanisms：mediate the adenosine triphospate-sensitive potassiun channels（KATP）,suppress the excessive releases of amine acid and inhibit the nitrogen monoxide production.However,Volatile anesthetiles on intracellular signal transduction pathways are still unclear.Recent research of toll-like receptors may provide new ideal and toll for studying the mechanisms of cerebral ischemial/reperfusion.This review describes the relevant research progress about volatile anesthetiles precondition-induced cerebral is-chemia/re-perfusion injury.

关 键 词：脑缺血再灌注 异氟烷预处理 TLRs受体 

分 类 号：Q95-3[生物学—动物学] R614[医药卫生—麻醉学]