CCR5抑制性多肽C25P的遗传毒性研究  

Study on the genotoxicity of CCR5 antagonist-C25P polypeptide

作　　者：莫雪梅[1] 孙晗笑[1] 汤曼莉[1] 李秀英[1] 张光[1] 

机构地区：[1]暨南大学药学院基因组药物研究所,广东广州510632

出　　处：《中国医院药学杂志》2010年第22期1883-1886,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金(编号:30872221);广州市重大科技计划(编号:2005Z1-E4081);广东省关键领域重大项目(编号:粤科计字[2005]162号)

摘　　要：目的:探讨C25P多肽的遗传毒性,为临床应用提供依据。方法:采用Ames试验检测C25P多肽的致基因突变作用;运用彗星试验检测C25P多肽对DNA的损伤作用;采用微核试验检测C25P多肽对染色体畸变的影响。结果:C25P多肽的Ames试验、彗星试验及微核试验结果均呈阴性。结论:C25P多肽不具有遗传毒性。OBJECTIVE To study the genotoxicity of C25P polypeptide and provide the basis for clinical application. METHODS Ames test was used to detect the mutagenesis of C25P polypeptide. Comet assay was used to detect the DNA damage of C25P polypeptide. Micronucleus test was used to detect the chromosome aberration of C25P polypeptide. RESULTS The re sults of Ames test, comet assay and micronucleus test were negative. CONCLUSION C25P polypeptide doesn＇t have genotoxicity.

关 键 词：遗传毒性 AMES试验 彗星试验 微核试验 C25P多肽 

分 类 号：R991[医药卫生—毒理学]