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出 处:《中国医院药学杂志》2010年第22期1926-1927,共2页Chinese Journal of Hospital Pharmacy
基 金:广西卫生厅科研课题资助项目(编号:Z2009022)
摘 要:目的:研究白饭树不同提取物(氯仿提取物及水提物)对小鼠佐剂性关节炎(AA)的治疗作用。方法:观察白饭树氯仿提取物及水提物对AA小鼠给药后继发性足肿胀、胸腺系数(胸腺/体质量)、脾系数(脾/体质量)的变化。结果:氯仿提取物组、水提物组,地塞米松组对小鼠继发性足肿胀有明显的抑制作用,减轻胸腺和脾脏质量。结论:白饭树中脂溶性物质和水溶性物质均可减轻AA小鼠继发性足肿胀。OBJECTIVE To study on the effects of different extracts of Flueggea virosa (Roxb. ex Willd. ) (extract of chloroform, extract of water) on adjuvant arthritis(AA) in mice. METHODS To observe the changes of secondary inflammation,the thymus factor (thymus/body weight) and spleen index( spleen/ body weight) of AA in mice after ig administration with extract of chloroform,extract of water. RESULTS Extract of chloroform (5 g. kg^-1 ), extract of water(5 g. kg-1 ) and dexamethasone (0. 001 g·kg^-1) ig could significantly inhibit secondary inflammatory swelling in AA models of mice and reduce the weight of thymus and spleen. CONCLUSION The lipid-soluble matters and the water-soluble matters of Flueggea virosa (Roxb. ex Willd. ) have therapeutic effect on AA in mice.
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