3种渗透促进剂对芒果苷离体角膜透过率的影响  

Effect of three penetration enhancers on corneal permeability of mangiferin in vitro

作　　者：刘睿[1] 刘志东[1] 舒乐新[1] 章臣桂 张伯礼[1] 

机构地区：[1]天津中医药大学现代中药发现与制剂技术教育部工程研究中心,天津300193 [2]天津中新药业技术中心,天津300193

出　　处：《中国中药杂志》2010年第23期3131-3135,共5页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973计划)项目(2005CB523404);国家科技支撑计划项目(2007BAI47B01);教育部科学技术研究重点项目(209002);国际科技合作项目(2007DFC31670)

摘　　要：目的：研究辛酸癸酸聚乙二醇甘油酯（labrasol,Lab）,聚乙二醇硬脂酸酯15（solutol HS 15,Sol）,二乙二醇单乙基醚（transcutol P,Trans）对芒果苷离体角膜透过率的影响。方法：采用离体扩散实验考察不同体积分数的3种渗透促进剂对芒果苷角膜透过率的影响。结果：Lab体积分数为1.0%,1.5%,2.0%,3.0%时,芒果苷的角膜表观渗透系数分别增加了1.80,3.27,3.41,4.76倍;Sol体积分数为0.2%,0.4%时,芒果苷的角膜表观渗透系数分别增加了1.98,3.07倍,与对照组相比均具有显著性差异（P〈0.01）,Trans体积分数为0.01%~0.03%时,芒果苷的角膜表观渗透系数并未增加。结论：Lab体积分数为1.0%~3.0%,Sol体积分数为0.2%~0.4%时,显著增加芒果苷的角膜表观渗透系数,而Trans体积分数为0.01%~0.03%时,不能增加芒果苷的角膜表观渗透系数。Objective： To investigate the effects of labrasol,solutol HS 15 and transcutol P on the corneal permeability of mangiferin in vitro.Method： The effects of three penetration enhancers on the corneal permeability of mangiferin were investigated in vitro by using isolated rabbit corneas.Result： The apparent Papp enhancements were increased 1.80,3.27,3.41 and 4.76-folds with Lab at 1.0%,1.5%,2.0% and 3.0%（P0.01）,respectively.The apparent Papp increased 1.98 and 3.07-folds with Sol at 0.2% and 0.4%（P0.01）,respectively,but reduced with 0.01%-0.03% Trans.Conclusion： The Papp value of mangiferin is significantly enhanced by 1.0%-3.0%Lab,0.2% and 0.4% Sol,however the Papp value of mangiferin is reduced by 0.01%-0.03% Trans.

关 键 词：LABRASOL solutol HS15 transcutol P 芒果苷 角膜透过 渗透促进剂 

分 类 号：R284[医药卫生—中药学]