氮杂冠醚、环糊精混合功能基键合硅胶液相色谱固定相的合成与评价  

Preparation and Evaluation of a Mixed Functional Stationary Phase Containing Crown Ether and Cyclodextrin for Highperformance Liquid Chromatography

作　　者：冯钰锜[1] 龚银汉[1] 达世禄[1] 

机构地区：[1]武汉大学化学学院

出　　处：《高等学校化学学报》1999年第4期552-554,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：冠醚键合固定相主要用于一些无机离子的分离，我们用连续固液相法合成了一系列冠醚键合硅胶固定相，并成功地用于有机化合物的分离［１～４］；β－ＣＤ的内腔疏水而外缘亲水，可以选择性地包结含苯环及萘环的化合物，且具有手性拆分能力，已被用于手性色谱固定相［５，...A mixed functional stationary phase containing aza crown ether and cyclodextrin for highperformance liquid chromatography was prepared via a continuous solidliquid reaction method. The new mixed functional stationary phase was used to separate some disubstituted benzene isomers such as nitrophenols, nitroanilines and phthalic acids. The results show that the separation ability of the new mixed functional stationary phase for the disubstituted benzene isomers is better than that on the aza crown ether bonded silica and cyclodextrin bonded silica stationary phases. Chiral separations of glycine derivatives, PMGly, MPGly and BPGly, were partially achieved on the new mixed functional stationary phase with phosphate buffer solution as the mobile phase.

关 键 词：液相色谱 冠醚 环糊精 键合硅胶 固定相 硅胶 

分 类 号：O657.720.3[理学—分析化学]